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10.12688/f1000research.10466.1 http://scihub22266oqcxt.onion/10.12688/f1000research.10466.1 C5321127!5321127!28299197     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       F1000Res 2017 ; 6 (ä): ä Nephropedia Template TP {{tp|p=28299197|t=2017. New insights into bacterial type II polyketide biosynthesis |pdf=|usr=}}{{28299197}} gab.com Text New insights into bacterial type II polyketide biosynthesis JO: F1000Res http://www.kidney.de/pget.php?&tw=1&pmid=28299197 #FOAvip Bacterial aromatic polyketides, exemplified by anthracyclines, angucyclines, tetracyclines, and pentangular polyphenols, are a large family of natural products with diverse structures and biological activities and are usually biosynthesized by type II polyketide synthases (PKSs). Since the starting point of biosynthesis and combinatorial biosynthesis in 1984?1985, there has been a continuous effort to investigate the biosynthetic logic of aromatic polyketides owing to the urgent need of developing promising therapeutic candidates from these compounds. Recently, significant advances in the structural and mechanistic identification of enzymes involved in aromatic polyketide biosynthesis have been made on the basis of novel genetic, biochemical, and chemical technologies. This review highlights the progress in bacterial type II PKSs in the past three years (2013?2016). Moreover, novel compounds discovered or created by genome mining and biosynthetic engineering are also included. Twit Text FOAVip New insights into bacterial type II polyketide biosynthesis ????F1000Res http://www.kidney.de/pget.php?&tw=1&pmid=28299197 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28299197 #FOAvip English Wikipedia <ref>{{Cite pmid|28299197}}</ref> New insights into bacterial type II polyketide biosynthesis #MMPMID28299197 Zhang Z; Pan HX; Tang GL F1000Res 2017[]; 6 (ä): ä PMID28299197show ga Bacterial aromatic polyketides, exemplified by anthracyclines, angucyclines, tetracyclines, and pentangular polyphenols, are a large family of natural products with diverse structures and biological activities and are usually biosynthesized by type II polyketide synthases (PKSs). Since the starting point of biosynthesis and combinatorial biosynthesis in 1984?1985, there has been a continuous effort to investigate the biosynthetic logic of aromatic polyketides owing to the urgent need of developing promising therapeutic candidates from these compounds. Recently, significant advances in the structural and mechanistic identification of enzymes involved in aromatic polyketide biosynthesis have been made on the basis of novel genetic, biochemical, and chemical technologies. This review highlights the progress in bacterial type II PKSs in the past three years (2013?2016). Moreover, novel compounds discovered or created by genome mining and biosynthetic engineering are also included. äNew insights into bacterial type II polyketide biosynthesis (epmc).pdf DeepDyve Pubget Overpricing