Recombination-mediated remodelling of host-pathogen interactions during
Staphylococcus aureus niche adaptation
#MMPMID28348819
Spoor LE
; Richardson E
; Richards AC
; Wilson GJ
; Mendonca C
; Gupta RK
; McAdam PR
; Nutbeam-Tuffs S
; Black NS
; O'Gara JP
; Lee CY
; Corander J
; Ross Fitzgerald J
Microb Genom
2015[Oct]; 1
(4
): e000036
PMID28348819
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Large-scale recombination events have led to the emergence of epidemic clones of
several major bacterial pathogens. However, the functional impact of the
recombination on clonal success is not understood. Here, we identified a novel
widespread hybrid clone (ST71) of livestock-associated Staphylococcus aureus that
evolved from an ancestor belonging to the major bovine lineage CC97, through
multiple large-scale recombination events with other S. aureus lineages occupying
the same ruminant niche. The recombination events, affecting a 329?kb region of
the chromosome spanning the origin of replication, resulted in allele replacement
and loss or gain of an array of genes influencing host-pathogen interactions. Of
note, molecular functional analyses revealed that the ST71 hybrid clone has
acquired multiple novel pathogenic traits associated with acquired and innate
immune evasion and bovine extracellular matrix adherence. These findings provide
a paradigm for the impact of large-scale recombination events on the rapid
evolution of bacterial pathogens within defined ecological niches.
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