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10.1038/srep43129 http://scihub22266oqcxt.onion/10.1038/srep43129 C5320503!5320503!28225025     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28225025|t=2017. Specific pathways mediating inflammasome activation by Candida parapsilosis |pdf=|usr=}}{{28225025}} gab.com Text Specific pathways mediating inflammasome activation by Candida parapsilosis JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28225025 #FOAvip Candida albicans and C. parapsilosis are human pathogens causing severe infections. The NLRP3 inflammasome plays a crucial role in host defence against C. albicans, but it has been previously unknown whether C. parapsilosis activates this complex. Here we show that C. parapsilosis induces caspase-1 activation and interleukin-1? (IL-1?) secretion in THP-1, as well as primary, human macrophages. IL-1? secretion was dependent on NLRP3, K+-efflux, TLR4, IRAK, Syk, caspase-1, caspase-8 and NADPH-oxidase. Importantly, while C. albicans induced robust IL-1? release after 4?h, C. parapsilosis was not able to stimulate the production of IL-1? after this short incubation period. We also found that C. parapsilosis was phagocytosed to a lesser extent, and induced significantly lower ROS production and lysosomal cathepsin B release compared to C. albicans, suggesting that the low extent of inflammasome activation by C. parapsilosis may result from a delay in the so-called ?signal 2?. In conclusion, this is the first study to examine the molecular pathways responsible for the IL-1? production in response to a non-albicans Candida species, and these results enhance our understanding about the immune response against C. parapsilosis. Twit Text FOAVip Specific pathways mediating inflammasome activation by Candida parapsilosis ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28225025 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28225025 #FOAvip English Wikipedia <ref>{{Cite pmid|28225025}}</ref> Specific pathways mediating inflammasome activation by Candida parapsilosis #MMPMID28225025 Tóth A; Zajta E; Csonka K; Vágvölgyi C; Netea MG; Gácser A Sci Rep 2017[]; 7 (ä): ä PMID28225025show ga Candida albicans and C. parapsilosis are human pathogens causing severe infections. The NLRP3 inflammasome plays a crucial role in host defence against C. albicans, but it has been previously unknown whether C. parapsilosis activates this complex. Here we show that C. parapsilosis induces caspase-1 activation and interleukin-1? (IL-1?) secretion in THP-1, as well as primary, human macrophages. IL-1? secretion was dependent on NLRP3, K+-efflux, TLR4, IRAK, Syk, caspase-1, caspase-8 and NADPH-oxidase. Importantly, while C. albicans induced robust IL-1? release after 4?h, C. parapsilosis was not able to stimulate the production of IL-1? after this short incubation period. We also found that C. parapsilosis was phagocytosed to a lesser extent, and induced significantly lower ROS production and lysosomal cathepsin B release compared to C. albicans, suggesting that the low extent of inflammasome activation by C. parapsilosis may result from a delay in the so-called ?signal 2?. In conclusion, this is the first study to examine the molecular pathways responsible for the IL-1? production in response to a non-albicans Candida species, and these results enhance our understanding about the immune response against C. parapsilosis. äSpecific pathways mediating inflammasome activation by Candida parapsi(epmc).pdf DeepDyve Pubget Overpricing