Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1126/science.aaf6742 http://scihub22266oqcxt.onion/10.1126/science.aaf6742 C5319821!5319821!27230373     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2016 ; 352 (6289): 1078-82 Nephropedia Template TP {{tp|p=27230373|t=2016. Enantioselective synthesis of an ophiobolin sesterterpene via a programmed radical cascade |pdf=|usr=}}{{27230373}} gab.com Text Enantioselective synthesis of an ophiobolin sesterterpene via a programmed radical cascade JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=27230373 #FOAvip Cyclase enzymes weave simple polyprenyl chains into the elaborate polycyclic ring systems of terpenes, a sequence that is often difficult to emulate under abiotic conditions. Herein we report a disparate synthetic approach to complex terpenes whereby simple prenyl-derived chains are cyclized using radical, rather than cationic, reaction pathways. This strategy efficiently forges challenging 5/8/5-fused ring systems found in numerous complex natural product classes and enabled a nine-step total synthesis of (?)-6-epi-ophiobolin N, a member of the large family of cytotoxic ophiobolin sesterterpenes. A small-molecule thiol catalyst was found to override the inherent diastereoselectivity observed during a reductive radical cascade cyclization process. This work lays the foundation for efficiently accessing historically challenging terpenoid ring systems of interest in medicinal research. Twit Text FOAVip Enantioselective synthesis of an ophiobolin sesterterpene via a programmed radical cascade ????Science http://www.kidney.de/pget.php?&tw=1&pmid=27230373 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27230373 #FOAvip English Wikipedia <ref>{{Cite pmid|27230373}}</ref> Enantioselective synthesis of an ophiobolin sesterterpene via a programmed radical cascade #MMPMID27230373 Brill ZG; Grover HK; Maimone TJ Science 2016[May]; 352 (6289): 1078-82 PMID27230373show ga Cyclase enzymes weave simple polyprenyl chains into the elaborate polycyclic ring systems of terpenes, a sequence that is often difficult to emulate under abiotic conditions. Herein we report a disparate synthetic approach to complex terpenes whereby simple prenyl-derived chains are cyclized using radical, rather than cationic, reaction pathways. This strategy efficiently forges challenging 5/8/5-fused ring systems found in numerous complex natural product classes and enabled a nine-step total synthesis of (?)-6-epi-ophiobolin N, a member of the large family of cytotoxic ophiobolin sesterterpenes. A small-molecule thiol catalyst was found to override the inherent diastereoselectivity observed during a reductive radical cascade cyclization process. This work lays the foundation for efficiently accessing historically challenging terpenoid ring systems of interest in medicinal research. äEnantioselective synthesis of an ophiobolin sesterterpene via a progra(epmc).pdf DeepDyve Pubget Overpricing