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10.2337/db16-1025 http://scihub22266oqcxt.onion/10.2337/db16-1025 C5319719!5319719!27920090     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Diabetes 2017 ; 66 (3): 722-34 Nephropedia Template TP {{tp|p=27920090|t=2017. Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes |pdf=|usr=}}{{27920090}} gab.com Text Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes JO: Diabetes http://www.kidney.de/pget.php?&tw=1&pmid=27920090 #FOAvip Type 1 diabetes results from chronic autoimmune destruction of insulin-producing ?-cells within pancreatic islets. Although insulin is a critical self-antigen in animal models of autoimmune diabetes, due to extremely limited access to pancreas samples, little is known about human antigenic targets for islet-infiltrating T cells. Here we show that proinsulin peptides are targeted by islet-infiltrating T cells from patients with type 1 diabetes. We identified hundreds of T cells from inflamed pancreatic islets of three young organ donors with type 1 diabetes with a short disease duration with high-risk HLA genes using a direct T-cell receptor (TCR) sequencing approach without long-term cell culture. Among 85 selected CD4 TCRs tested for reactivity to preproinsulin peptides presented by diabetes-susceptible HLA-DQ and HLA-DR molecules, one T cell recognized C-peptide amino acids 19?35, and two clones from separate donors responded to insulin B-chain amino acids 9?23 (B:9?23), which are known to be a critical self-antigen?driving disease progress in animal models of autoimmune diabetes. These B:9?23?specific T cells from islets responded to whole proinsulin and islets, whereas previously identified B:9?23 responsive clones from peripheral blood did not, highlighting the importance of proinsulin-specific T cells in the islet microenvironment. Twit Text FOAVip Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes ????Diabetes http://www.kidney.de/pget.php?&tw=1&pmid=27920090 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27920090 #FOAvip English Wikipedia <ref>{{Cite pmid|27920090}}</ref> Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes #MMPMID27920090 Michels AW; Landry LG; McDaniel KA; Yu L; Campbell-Thompson M; Kwok WW; Jones KL; Gottlieb PA; Kappler JW; Tang Q; Roep BO; Atkinson MA; Mathews CE; Nakayama M Diabetes 2017[Mar]; 66 (3): 722-34 PMID27920090show ga Type 1 diabetes results from chronic autoimmune destruction of insulin-producing ?-cells within pancreatic islets. Although insulin is a critical self-antigen in animal models of autoimmune diabetes, due to extremely limited access to pancreas samples, little is known about human antigenic targets for islet-infiltrating T cells. Here we show that proinsulin peptides are targeted by islet-infiltrating T cells from patients with type 1 diabetes. We identified hundreds of T cells from inflamed pancreatic islets of three young organ donors with type 1 diabetes with a short disease duration with high-risk HLA genes using a direct T-cell receptor (TCR) sequencing approach without long-term cell culture. Among 85 selected CD4 TCRs tested for reactivity to preproinsulin peptides presented by diabetes-susceptible HLA-DQ and HLA-DR molecules, one T cell recognized C-peptide amino acids 19?35, and two clones from separate donors responded to insulin B-chain amino acids 9?23 (B:9?23), which are known to be a critical self-antigen?driving disease progress in animal models of autoimmune diabetes. These B:9?23?specific T cells from islets responded to whole proinsulin and islets, whereas previously identified B:9?23 responsive clones from peripheral blood did not, highlighting the importance of proinsulin-specific T cells in the islet microenvironment. äIslet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Dia(epmc).pdf DeepDyve Pubget Overpricing