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10.1159/000448381 http://scihub22266oqcxt.onion/10.1159/000448381 C5318919!5318919!28275334     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Transfus+Med+Hemother 2017 ; 44 (1): 53-7 Nephropedia Template TP {{tp|p=28275334|t=2017. Clinical Significance of an Alloantibody against the Kell Blood Group Glycoprotein |pdf=|usr=}}{{28275334}} gab.com Text Clinical Significance of an Alloantibody against the Kell Blood Group Glycoprotein JO: Transfus Med Hemother http://www.kidney.de/pget.php?&tw=1&pmid=28275334 #FOAvip Background: Kell null (K0) individuals can produce anti-Ku, an antibody against many epitopes in the Kell glycoprotein, after transfusion and/or pregnancy. Since sensitized K0 patients are rare, little is known about anti-Ku clinical relevance and in particular about its association to hemolytic disease of the fetus and newborn. Case Report: This work describes a case of neonatal hyperbilirubinemia due to immune-mediated erythrocyte destruction by an alloantibody directed against the Kell glycoprotein. Serologic and molecular approaches identified an anti-Ku alloantibody in maternal serum. A homozygous IVS3 + 1g>a point mutation (KEL*02N.06 allele) was found to be responsible for the lack of Kell antigen expression in the mother's red blood cell and subsequent alloimmunization after a previous pregnancy. Even though in most cases Kell antibodies are clinically severe and may cause suppression of erythropoiesis, in our case the newborn had a moderate anemia and hyperbilirubinemia that was successfully treated with phototherapy without requiring exchange transfusion. Serological and molecular studies performed in the proband's family members allowed us to provide them with proper counseling regarding alloimmunization after transfusion and/or pregnancy. Conclusions: This case enlarges the understanding of the clinical significance of alloantibodies against Kell blood group antigens. Twit Text FOAVip Clinical Significance of an Alloantibody against the Kell Blood Group Glycoprotein ????Transfus Med Hemother http://www.kidney.de/pget.php?&tw=1&pmid=28275334 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28275334 #FOAvip English Wikipedia <ref>{{Cite pmid|28275334}}</ref> Clinical Significance of an Alloantibody against the Kell Blood Group Glycoprotein #MMPMID28275334 Mattaloni SM; Arnoni C; Céspedes R; Nonaka C; Trucco Boggione C; Luján Brajovich ME; Trejo A; Zani N; Biondi CS; Castilho L; Cotorruelo CM Transfus Med Hemother 2017[Jan]; 44 (1): 53-7 PMID28275334show ga Background: Kell null (K0) individuals can produce anti-Ku, an antibody against many epitopes in the Kell glycoprotein, after transfusion and/or pregnancy. Since sensitized K0 patients are rare, little is known about anti-Ku clinical relevance and in particular about its association to hemolytic disease of the fetus and newborn. Case Report: This work describes a case of neonatal hyperbilirubinemia due to immune-mediated erythrocyte destruction by an alloantibody directed against the Kell glycoprotein. Serologic and molecular approaches identified an anti-Ku alloantibody in maternal serum. A homozygous IVS3 + 1g>a point mutation (KEL*02N.06 allele) was found to be responsible for the lack of Kell antigen expression in the mother's red blood cell and subsequent alloimmunization after a previous pregnancy. Even though in most cases Kell antibodies are clinically severe and may cause suppression of erythropoiesis, in our case the newborn had a moderate anemia and hyperbilirubinemia that was successfully treated with phototherapy without requiring exchange transfusion. Serological and molecular studies performed in the proband's family members allowed us to provide them with proper counseling regarding alloimmunization after transfusion and/or pregnancy. Conclusions: This case enlarges the understanding of the clinical significance of alloantibodies against Kell blood group antigens. äClinical Significance of an Alloantibody against the Kell Blood Group (epmc).pdf DeepDyve Pubget Overpricing