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10.1155/2017/8679841 http://scihub22266oqcxt.onion/10.1155/2017/8679841 C5318619!5318619 !28265584     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28265584 &cmd=llinks): Failed to open stream: HTTP request failed! 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Analysis of Sera of Recipients with Allograft Rejection Indicates That Keratin 1 Is the Target of Anti-Endothelial Antibodies |pdf=|usr=}}{{28265584 }} gab.com Text Analysis of Sera of Recipients with Allograft Rejection Indicates That Keratin 1 Is the Target of Anti-Endothelial Antibodies JO: J Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=28265584 #FOAvip Anti-endothelial cell antibodies (AECAs) are usually directed against the surface antigens on the vascular endothelial cells. Clinical studies suggest a pathogenic role for nonhuman leukocyte antigen in antibody-mediated rejection; however, the antigens on the donor vascular endothelium that serve as the first-line targets for an immune response during allograft rejection have not been fully identified. Here, we used immunoprecipitation and mass spectrometry to identify antigens from the sera of kidney transplant recipients who were experiencing antibody-mediated rejection. Keratin 1 (KRT1) was identified as a novel antigenic target expressed on endothelial cells. To validate our finding, we produced recombinant proteins representing the three most common alleles of KRT1. The serum used for immunoprecipitation showed a strong reaction to KRT1 recombinants in western blot and ELISA. In the kidney transplant cohort, more AECA-positive recipients than AECA-negative recipients had KRT1 antibodies (32.2% versus 11.9%, p = 0.002). Sera from 255 renal recipients were tested by ELISA. Of the 77 recipients with deteriorating graft function (serum creatinine > 120??mol/L), 23 had anti-KRT1 antibodies. KRT1-IgG positivity was, therefore, associated with a higher risk of kidney transplant rejection (29.9% (23/77) versus 16.9% (30/178), p = 0.0187). A better understanding of this antigenic target will improve long-term allograft survival. Twit Text FOAVip Analysis of Sera of Recipients with Allograft Rejection Indicates That Keratin 1 Is the Target of Anti-Endothelial Antibodies ????J Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=28265584 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28265584 #FOAvip English Wikipedia <ref>{{Cite pmid|28265584 }}</ref> Analysis of Sera of Recipients with Allograft Rejection Indicates That Keratin 1 Is the Target of Anti-Endothelial Antibodies #MMPMID28265584 Guo X ; Hu J ; Luo W ; Luo Q ; Guo J ; Tian F ; Ming Y ; Zou Y J Immunol Res 2017[]; 2017 (ä): 8679841 PMID28265584 show ga Anti-endothelial cell antibodies (AECAs) are usually directed against the surface antigens on the vascular endothelial cells. Clinical studies suggest a pathogenic role for nonhuman leukocyte antigen in antibody-mediated rejection; however, the antigens on the donor vascular endothelium that serve as the first-line targets for an immune response during allograft rejection have not been fully identified. Here, we used immunoprecipitation and mass spectrometry to identify antigens from the sera of kidney transplant recipients who were experiencing antibody-mediated rejection. Keratin 1 (KRT1) was identified as a novel antigenic target expressed on endothelial cells. To validate our finding, we produced recombinant proteins representing the three most common alleles of KRT1. The serum used for immunoprecipitation showed a strong reaction to KRT1 recombinants in western blot and ELISA. In the kidney transplant cohort, more AECA-positive recipients than AECA-negative recipients had KRT1 antibodies (32.2% versus 11.9%, p = 0.002). Sera from 255 renal recipients were tested by ELISA. Of the 77 recipients with deteriorating graft function (serum creatinine > 120??mol/L), 23 had anti-KRT1 antibodies. KRT1-IgG positivity was, therefore, associated with a higher risk of kidney transplant rejection (29.9% (23/77) versus 16.9% (30/178), p = 0.0187). A better understanding of this antigenic target will improve long-term allograft survival. |Allografts/immunology [MESH] |Antigens/*blood [MESH] |Autoantibodies/blood/*immunology [MESH] |Endothelial Cells/immunology [MESH] |Enzyme-Linked Immunosorbent Assay [MESH] |Female [MESH] |Graft Rejection/*immunology [MESH] |Graft Survival/immunology [MESH] |Humans [MESH] |Immunoglobulin G/blood/immunology/isolation & purification [MESH] |Immunoprecipitation [MESH] |Keratin-1/blood/genetics/*immunology [MESH] |Kidney Transplantation/adverse effects [MESH] |Male [MESH] |Mass Spectrometry [MESH] |Middle Aged [MESH] |Polymerase Chain Reaction [MESH]Analysis of Sera of Recipients with Allograft Rejection Indicates That(epmc).pdf DeepDyve Pubget Overpricing