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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Front+Microbiol 2017 ; 8 (ä): ä Nephropedia Template TP
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Participation of Leukotrienes in the Immune Modulation of Oral Tolerance #MMPMID28270799
de Oliveira SRP; Nomizo A; Frantz FG; Faccioli LH; de Matos APK; Carrilho E; Afonso A; de Freitas Anibal F
Front Microbiol 2017[]; 8 (ä): ä PMID28270799show ga
Oral tolerance (OT) is characterized as a peripheral immune tolerance form, in which, mature lymphocytes in lymphoid tissues associated with mucosa, become non-functional or hypo responsive due to prior oral administration of antigen. OT is an important immunological phenomenon due to its therapeutic potential in inflammatory processes and others diseases. Here we evaluated leukotriene role in the induction of OT, as well as, the production of cytokines IL-5 and IFN-? in leukotriene deficient animals (knock-out). Our results suggested that even in the presence of OT and leukotrienes absence, cytokine IFN-? remains being secreted, which gives us an indication of immune system specificity and also that IFN-? participates in various immune processes.