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Molecular mechanisms of Sox transcription factors during the development of
liver, bile duct, and pancreas
#MMPMID27552918
Yin C
Semin Cell Dev Biol
2017[Mar]; 63
(?): 68-78
PMID27552918
show ga
The liver and pancreas are the prime digestive and metabolic organs in the body.
After emerging from the neighboring domains of the foregut endoderm, they turn on
distinct differentiation and morphogenesis programs that are regulated by
hierarchies of transcription factors. Members of SOX family of transcription
factors are expressed in the liver and pancreas throughout development and act
upstream of other organ-specific transcription factors. They play key roles in
maintaining stem cells and progenitors. They are also master regulators of cell
fate determination and tissue morphogenesis. In this review, we summarize the
current understanding of SOX transcription factors in mediating liver and
pancreas development. We discuss their contribution to adult organ function,
homeostasis and injury responses. We also speculate how the knowledge of SOX
transcription factors can be applied to improve therapies for liver diseases and
diabetes.
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