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10.1016/j.canlet.2015.12.022 http://scihub22266oqcxt.onion/10.1016/j.canlet.2015.12.022 C5317350!5317350!26828013     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Lett 2016 ; 380 (1): 340-8 Nephropedia Template TP {{tp|p=26828013|t=2016. Regulation of Prostate Cancer Progression by the Tumor Microenvironment |pdf=|usr=}}{{26828013}} gab.com Text Regulation of Prostate Cancer Progression by the Tumor Microenvironment JO: Cancer Lett http://www.kidney.de/pget.php?&tw=1&pmid=26828013 #FOAvip Prostate cancer remains the most frequently diagnosed cancer in men in North America, and despite recent advances in treatment patients with metastatic disease continue to have poor five-year survival rates. Recent studies in prostate cancer have revealed the critical role of the tumor microenvironment in the initiation and progression to advanced disease . Experimental data has uncovered a reciprocal relationship between the cells in the microenvironment and malignant tumor cells in which early changes in normal tissue microenvironment can promote tumorigenesis and in turn tumor cells can promote further pro-tumor changes in the microenvironment. In the tumor microenvironment, the presence of persistent immune infiltrates contributes to the recruitment and reprogramming of other non-immune stromal cells including cancer-associated fibroblasts and a unique recently identified population of metastasis-initiating cells (MICs). These MICs, which can also be found as part of the circulating tumor cell (CTC) population in PC patients, promote cancer cell transformation, enhance metastatic potential and confer therapeutic resistance. MICs act can on other cells within the tumor microenvironment in part by secreting exosomes that reprogram adjacent stromal cells to create a more favorable tumor microenvironment to support continued cancer growth and progression. We review here the current data on the intricate relationship between inflammation, reactive stroma, tumor cells and disease progression in prostate cancer. Twit Text FOAVip Regulation of Prostate Cancer Progression by the Tumor Microenvironment ????Cancer Lett http://www.kidney.de/pget.php?&tw=1&pmid=26828013 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26828013 #FOAvip English Wikipedia <ref>{{Cite pmid|26828013}}</ref> Regulation of Prostate Cancer Progression by the Tumor Microenvironment #MMPMID26828013 Shiao SL; Chu GCY; Chung LWK Cancer Lett 2016[Sep]; 380 (1): 340-8 PMID26828013show ga Prostate cancer remains the most frequently diagnosed cancer in men in North America, and despite recent advances in treatment patients with metastatic disease continue to have poor five-year survival rates. Recent studies in prostate cancer have revealed the critical role of the tumor microenvironment in the initiation and progression to advanced disease . Experimental data has uncovered a reciprocal relationship between the cells in the microenvironment and malignant tumor cells in which early changes in normal tissue microenvironment can promote tumorigenesis and in turn tumor cells can promote further pro-tumor changes in the microenvironment. In the tumor microenvironment, the presence of persistent immune infiltrates contributes to the recruitment and reprogramming of other non-immune stromal cells including cancer-associated fibroblasts and a unique recently identified population of metastasis-initiating cells (MICs). These MICs, which can also be found as part of the circulating tumor cell (CTC) population in PC patients, promote cancer cell transformation, enhance metastatic potential and confer therapeutic resistance. MICs act can on other cells within the tumor microenvironment in part by secreting exosomes that reprogram adjacent stromal cells to create a more favorable tumor microenvironment to support continued cancer growth and progression. We review here the current data on the intricate relationship between inflammation, reactive stroma, tumor cells and disease progression in prostate cancer. äRegulation of Prostate Cancer Progression by the Tumor Microenvironmen(epmc).pdf DeepDyve Pubget Overpricing