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10.4254/wjh.v9.i5.288

http://scihub22266oqcxt.onion/10.4254/wjh.v9.i5.288
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C5316849!5316849!28261386
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suck abstract from ncbi


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pmid28261386      World+J+Hepatol 2017 ; 9 (5): 288-92
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  • Is it time to rethink combined liver-kidney transplant in hepatitis C patients with advanced fibrosis? #MMPMID28261386
  • Shah NJ; Russo MW
  • World J Hepatol 2017[Feb]; 9 (5): 288-92 PMID28261386show ga
  • AIM: To reduce hepatic and extrahepatic complications of chronic hepatitis C in kidney transplant recipients. METHODS: We conducted a systematic review of kidney only transplant in patients with hepatitis C and advanced fibrosis. RESULTS: The 5 year patient survival of kidney transplant recipients with and without hepatitis C cirrhosis ranged from 31% to 90% and 85% to 92%, respectively. Hepatitis C kidney transplant recipients had lower 10-year survival when compared to hepatitis B patients, 40% and 90% respectively. There were no studies that included patients with virologic cure prior to kidney transplant that reported post-kidney transplant outcomes. There were no studies of direct acting antiviral therapy and effect on patient or graft survival after kidney transplantation. CONCLUSION: Data on kidney transplant only in hepatitis C patients that reported inferior outcomes were prior to the development of potent direct acting antiviral. With the development of potent directing acting antiviral therapy for hepatitis C with high cure rates studies are needed to determine if patients with hepatitis C, including those with advanced fibrosis, can undergo kidney transplant alone with acceptable long term outcomes.
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