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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Front+Microbiol 2017 ; 8 (ä): ä Nephropedia Template TP
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Role of Streptococcus pneumoniae Proteins in Evasion of Complement-Mediated Immunity #MMPMID28265264
Andre GO; Converso TR; Politano WR; Ferraz LFC; Ribeiro ML; Leite LCC; Darrieux M
Front Microbiol 2017[]; 8 (ä): ä PMID28265264show ga
The complement system plays a central role in immune defense against Streptococcus pneumoniae. In order to evade complement attack, pneumococci have evolved a number of mechanisms that limit complement mediated opsonization and subsequent phagocytosis. This review focuses on the strategies employed by pneumococci to circumvent complement mediated immunity, both in vitro and in vivo. At last, since many of the proteins involved in interactions with complement components are vaccine candidates in different stages of validation, we explore the use of these antigens alone or in combination, as potential vaccine approaches that aim at elimination or drastic reduction in the ability of this bacterium to evade complement.