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Protein bio-corona: critical issue in immune nanotoxicology #MMPMID27438349
Neagu M; Piperigkou Z; Karamanou K; Engin AB; Docea AO; Constantin C; Negrei C; Nikitovic D; Tsatsakis A
Arch Toxicol 2017[]; 91 (3): 1031-48 PMID27438349show ga
With the expansion of the nanomedicine field, the knowledge focusing on the behavior of nanoparticles in the biological milieu has rapidly escalated. Upon introduction to a complex biological system, nanomaterials dynamically interact with all the encountered biomolecules and form the protein ?bio-corona.? The decoration with these surface biomolecules endows nanoparticles with new properties. The present review will address updates of the protein bio-corona characteristics as influenced by nanoparticle?s physicochemical properties and by the particularities of the encountered biological milieu. Undeniably, bio-corona generation influences the efficacy of the nanodrug and guides the actions of innate and adaptive immunity. Exploiting the dynamic process of protein bio-corona development in combination with the new engineered horizons of drugs linked to nanoparticles could lead to innovative functional nanotherapies. Therefore, bio-medical nanotechnologies should focus on the interactions of nanoparticles with the immune system for both safety and efficacy reasons.