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10.1016/j.mcn.2016.12.006 http://scihub22266oqcxt.onion/10.1016/j.mcn.2016.12.006 C5315639!5315639!28040512     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cell+Neurosci 2017 ; 79 (ä): 12-22 Nephropedia Template TP {{tp|p=28040512|t=2017. Extracellular vesicles of the blood-brain barrier: role in the HIV-1 associated amyloid beta pathology |pdf=|usr=}}{{28040512}} gab.com Text Extracellular vesicles of the blood-brain barrier: role in the HIV-1 associated amyloid beta pathology JO: Mol Cell Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=28040512 #FOAvip HIV-infected brains are characterized by increased amyloid beta (A?) deposition. It is believed that the blood-brain barrier (BBB) is critical for A? homeostasis and contributes to A? accumulation in the brain. Extracellular vesicles (ECV), like exosomes, recently gained a lot of attention as potentially playing a significant role in A? pathology. In addition, HIV-1 hijacks the exosomal pathway for budding and release. Therefore, we investigated the involvement of BBB-derived ECV in the HIV-1-induced A? pathology in the brain. Our results indicate that HIV-1 increases ECV release from brain endothelial cells as well as elevates their A? cargo when compared to controls. Interestingly, brain endothelial cell-derived ECV transferred A? to astrocytes and pericytes. Infusion of brain endothelial ECV carrying fluorescent A? into the internal carotid artery of mice resulted in A? fluorescence associated with brain microvessels and in the brain parenchyma. These results suggest that ECV carrying A? can be successfully transferred across the BBB into the brain. Based on these observations, we conclude that HIV-1 facilitates the shedding of brain endothelial ECV carrying A?; a process that may increase A? exposure of cells of neurovascular unit, and contribute to amyloid deposition in HIV-infected brain. Twit Text FOAVip Extracellular vesicles of the blood-brain barrier: role in the HIV-1 associated amyloid beta pathology ????Mol Cell Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=28040512 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28040512 #FOAvip English Wikipedia <ref>{{Cite pmid|28040512}}</ref> Extracellular vesicles of the blood-brain barrier: role in the HIV-1 associated amyloid beta pathology #MMPMID28040512 András IE; Leda A; Contreras MG; Bertrand L; Park M; Skowronska M; Toborek M Mol Cell Neurosci 2017[Mar]; 79 (ä): 12-22 PMID28040512show ga HIV-infected brains are characterized by increased amyloid beta (A?) deposition. It is believed that the blood-brain barrier (BBB) is critical for A? homeostasis and contributes to A? accumulation in the brain. Extracellular vesicles (ECV), like exosomes, recently gained a lot of attention as potentially playing a significant role in A? pathology. In addition, HIV-1 hijacks the exosomal pathway for budding and release. Therefore, we investigated the involvement of BBB-derived ECV in the HIV-1-induced A? pathology in the brain. Our results indicate that HIV-1 increases ECV release from brain endothelial cells as well as elevates their A? cargo when compared to controls. Interestingly, brain endothelial cell-derived ECV transferred A? to astrocytes and pericytes. Infusion of brain endothelial ECV carrying fluorescent A? into the internal carotid artery of mice resulted in A? fluorescence associated with brain microvessels and in the brain parenchyma. These results suggest that ECV carrying A? can be successfully transferred across the BBB into the brain. Based on these observations, we conclude that HIV-1 facilitates the shedding of brain endothelial ECV carrying A?; a process that may increase A? exposure of cells of neurovascular unit, and contribute to amyloid deposition in HIV-infected brain. äExtracellular vesicles of the blood-brain barrier: role in the HIV-1 a(epmc).pdf DeepDyve Pubget Overpricing