Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.mcn.2016.12.006 http://scihub22266oqcxt.onion/10.1016/j.mcn.2016.12.006 C5315639!5315639 !28040512     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28040512 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28040512 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Cell+Neurosci 2017 ; 79 (ä): 12-22 Nephropedia Template TP {{tp|p=28040512 |t=2017. Extracellular vesicles of the blood-brain barrier: Role in the HIV-1 associated amyloid beta pathology |pdf=|usr=}}{{28040512 }} gab.com Text Extracellular vesicles of the blood-brain barrier: Role in the HIV-1 associated amyloid beta pathology JO: Mol Cell Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=28040512 #FOAvip HIV-infected brains are characterized by increased amyloid beta (A?) deposition. It is believed that the blood-brain barrier (BBB) is critical for A? homeostasis and contributes to A? accumulation in the brain. Extracellular vesicles (ECV), like exosomes, recently gained a lot of attention as potentially playing a significant role in A? pathology. In addition, HIV-1 hijacks the exosomal pathway for budding and release. Therefore, we investigated the involvement of BBB-derived ECV in the HIV-1-induced A? pathology in the brain. Our results indicate that HIV-1 increases ECV release from brain endothelial cells as well as elevates their A? cargo when compared to controls. Interestingly, brain endothelial cell-derived ECV transferred A? to astrocytes and pericytes. Infusion of brain endothelial ECV carrying fluorescent A? into the internal carotid artery of mice resulted in A? fluorescence associated with brain microvessels and in the brain parenchyma. These results suggest that ECV carrying A? can be successfully transferred across the BBB into the brain. Based on these observations, we conclude that HIV-1 facilitates the shedding of brain endothelial ECV carrying A?; a process that may increase A? exposure of cells of neurovascular unit, and contribute to amyloid deposition in HIV-infected brain. Twit Text FOAVip Extracellular vesicles of the blood-brain barrier: Role in the HIV-1 associated amyloid beta pathology ????Mol Cell Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=28040512 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28040512 #FOAvip English Wikipedia <ref>{{Cite pmid|28040512 }}</ref> Extracellular vesicles of the blood-brain barrier: Role in the HIV-1 associated amyloid beta pathology #MMPMID28040512 András IE ; Leda A ; Contreras MG ; Bertrand L ; Park M ; Skowronska M ; Toborek M Mol Cell Neurosci 2017[Mar]; 79 (ä): 12-22 PMID28040512 show ga HIV-infected brains are characterized by increased amyloid beta (A?) deposition. It is believed that the blood-brain barrier (BBB) is critical for A? homeostasis and contributes to A? accumulation in the brain. Extracellular vesicles (ECV), like exosomes, recently gained a lot of attention as potentially playing a significant role in A? pathology. In addition, HIV-1 hijacks the exosomal pathway for budding and release. Therefore, we investigated the involvement of BBB-derived ECV in the HIV-1-induced A? pathology in the brain. Our results indicate that HIV-1 increases ECV release from brain endothelial cells as well as elevates their A? cargo when compared to controls. Interestingly, brain endothelial cell-derived ECV transferred A? to astrocytes and pericytes. Infusion of brain endothelial ECV carrying fluorescent A? into the internal carotid artery of mice resulted in A? fluorescence associated with brain microvessels and in the brain parenchyma. These results suggest that ECV carrying A? can be successfully transferred across the BBB into the brain. Based on these observations, we conclude that HIV-1 facilitates the shedding of brain endothelial ECV carrying A?; a process that may increase A? exposure of cells of neurovascular unit, and contribute to amyloid deposition in HIV-infected brain. |AIDS Dementia Complex/*metabolism [MESH] |Amyloid beta-Peptides/*metabolism/toxicity [MESH] |Animals [MESH] |Blood-Brain Barrier/*metabolism/virology [MESH] |Cell Line [MESH] |Cells, Cultured [MESH] |Endothelium, Vascular/metabolism/virology [MESH] |Extracellular Vesicles/*metabolism [MESH] |HEK293 Cells [MESH] |HIV-1/pathogenicity [MESH] |Humans [MESH] |Male [MESH] |Mice [MESH]Extracellular vesicles of the blood-brain barrier: Role in the HIV-1 a(epmc).pdf DeepDyve Pubget Overpricing