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A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.kint.2016.09.030 http://scihub22266oqcxt.onion/10.1016/j.kint.2016.09.030 C5313343!5313343 !27927603     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27927603 &cmd=llinks): Failed to open stream: HTTP request failed! 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Lysophosphatidic acid signaling through its receptor initiates profibrotic epithelial cell fibroblast communication mediated by epithelial cell derived connective tissue growth factor |pdf=|usr=}}{{27927603 }} gab.com Text Lysophosphatidic acid signaling through its receptor initiates profibrotic epithelial cell fibroblast communication mediated by epithelial cell derived connective tissue growth factor JO: Kidney Int http://www.kidney.de/pget.php?&tw=1&pmid=27927603 #FOAvip The expansion of the fibroblast pool is a critical step in organ fibrosis, but the mechanisms driving expansion remain to be fully clarified. We previously showed that lysophosphatidic acid (LPA) signaling through its receptor LPA(1) expressed on fibroblasts directly induces the recruitment of these cells. Here we tested whether LPA-LPA(1) signaling drives fibroblast proliferation and activation during the development of renal fibrosis. LPA(1)-deficient (LPA(1)(-/-)) or -sufficient (LPA(1)(+/+)) mice were crossed to mice with green fluorescent protein expression (GFP) driven by the type I procollagen promoter (Col-GFP) to identify fibroblasts. Unilateral ureteral obstruction-induced increases in renal collagen were significantly, though not completely, attenuated in LPA(1)(-/-)Col-GFP mice, as were the accumulations of both fibroblasts and myofibroblasts. Connective tissue growth factor was detected mainly in tubular epithelial cells, and its levels were suppressed in LPA(1)(-/-)Col-GFP mice. LPA-LPA(1) signaling directly induced connective tissue growth factor expression in primary proximal tubular epithelial cells, through a myocardin-related transcription factor-serum response factor pathway. Proximal tubular epithelial cell-derived connective tissue growth factor mediated renal fibroblast proliferation and myofibroblast differentiation. Administration of an inhibitor of myocardin-related transcription factor/serum response factor suppressed obstruction-induced renal fibrosis. Thus, targeting LPA-LPA(1) signaling and/or myocardin-related transcription factor/serum response factor-induced transcription could be promising therapeutic strategies for renal fibrosis. Twit Text FOAVip Lysophosphatidic acid signaling through its receptor initiates profibrotic epithelial cell fibroblast communication mediated by epithelial cell derived connective tissue growth factor ????Kidney Int http://www.kidney.de/pget.php?&tw=1&pmid=27927603 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27927603 #FOAvip English Wikipedia <ref>{{Cite pmid|27927603 }}</ref> Lysophosphatidic acid signaling through its receptor initiates profibrotic epithelial cell fibroblast communication mediated by epithelial cell derived connective tissue growth factor #MMPMID27927603 Sakai N ; Chun J ; Duffield JS ; Lagares D ; Wada T ; Luster AD ; Tager AM Kidney Int 2017[Mar]; 91 (3 ): 628-641 PMID27927603 show ga The expansion of the fibroblast pool is a critical step in organ fibrosis, but the mechanisms driving expansion remain to be fully clarified. We previously showed that lysophosphatidic acid (LPA) signaling through its receptor LPA(1) expressed on fibroblasts directly induces the recruitment of these cells. Here we tested whether LPA-LPA(1) signaling drives fibroblast proliferation and activation during the development of renal fibrosis. LPA(1)-deficient (LPA(1)(-/-)) or -sufficient (LPA(1)(+/+)) mice were crossed to mice with green fluorescent protein expression (GFP) driven by the type I procollagen promoter (Col-GFP) to identify fibroblasts. Unilateral ureteral obstruction-induced increases in renal collagen were significantly, though not completely, attenuated in LPA(1)(-/-)Col-GFP mice, as were the accumulations of both fibroblasts and myofibroblasts. Connective tissue growth factor was detected mainly in tubular epithelial cells, and its levels were suppressed in LPA(1)(-/-)Col-GFP mice. LPA-LPA(1) signaling directly induced connective tissue growth factor expression in primary proximal tubular epithelial cells, through a myocardin-related transcription factor-serum response factor pathway. Proximal tubular epithelial cell-derived connective tissue growth factor mediated renal fibroblast proliferation and myofibroblast differentiation. Administration of an inhibitor of myocardin-related transcription factor/serum response factor suppressed obstruction-induced renal fibrosis. Thus, targeting LPA-LPA(1) signaling and/or myocardin-related transcription factor/serum response factor-induced transcription could be promising therapeutic strategies for renal fibrosis. |Animals [MESH] |Cell Communication/*drug effects [MESH] |Cell Proliferation/drug effects [MESH] |Cells, Cultured [MESH] |Collagen Type I/genetics [MESH] |Connective Tissue Growth Factor/*metabolism [MESH] |Disease Models, Animal [MESH] |Dose-Response Relationship, Drug [MESH] |Epithelial Cells/*drug effects/metabolism/pathology [MESH] |Fibroblasts/*drug effects/metabolism/pathology [MESH] |Fibrosis [MESH] |Genotype [MESH] |Green Fluorescent Proteins/genetics/metabolism [MESH] |Kidney Diseases/genetics/*metabolism/pathology/prevention & control [MESH] |Kidney/*drug effects/metabolism/pathology [MESH] |Lysophospholipids/*pharmacology [MESH] |Mice, Knockout [MESH] |Myofibroblasts/drug effects/metabolism/pathology [MESH] |Phenotype [MESH] |Promoter Regions, Genetic [MESH] |RNA Interference [MESH] |Receptors, Lysophosphatidic Acid/*agonists/deficiency/genetics/metabolism [MESH] |Serum Response Factor/metabolism [MESH] |Signal Transduction/*drug effects [MESH] |Trans-Activators/metabolism [MESH] |Transcription Factors/metabolism [MESH] |Transfection [MESH]Lysophosphatidic acid signaling through its receptor initiates profibr(epmc).pdf DeepDyve Pubget Overpricing