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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 PLoS+One 2017 ; 12 (2): ä Nephropedia Template TP
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The ins and outs of eukaryotic viruses: Knowledge base and ontology of a viral infection #MMPMID28207819
Hulo C; Masson P; de Castro E; Auchincloss AH; Foulger R; Poux S; Lomax J; Bougueleret L; Xenarios I; Le Mercier P
PLoS One 2017[]; 12 (2): ä PMID28207819show ga
Viruses are genetically diverse, infect a wide range of tissues and host cells and follow unique processes for replicating themselves. All these processes were investigated and indexed in ViralZone knowledge base. To facilitate standardizing data, a simple ontology of viral life-cycle terms was developed to provide a common vocabulary for annotating data sets. New terminology was developed to address unique viral replication cycle processes, and existing terminology was modified and adapted. The virus life-cycle is classically described by schematic pictures. Using this ontology, it can be represented by a combination of successive terms: ?entry?, ?latency?, ?transcription?, ?replication? and ?exit?. Each of these parts is broken down into discrete steps. For example Zika virus ?entry? is broken down in successive steps: ?Attachment?, ?Apoptotic mimicry?, ?Viral endocytosis/ macropinocytosis?, ?Fusion with host endosomal membrane?, ?Viral factory?. To demonstrate the utility of a standard ontology for virus biology, this work was completed by annotating virus data in the ViralZone, UniProtKB and Gene Ontology databases.