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10.18632/oncotarget.11356 http://scihub22266oqcxt.onion/10.18632/oncotarget.11356 C5312274!5312274!27542215     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2016 ; 7 (37): 58768-78 Nephropedia Template TP {{tp|p=27542215|t=2016. Zbtb1 prevents default myeloid differentiation of lymphoid-primed multipotent progenitors |pdf=|usr=}}{{27542215}} gab.com Text Zbtb1 prevents default myeloid differentiation of lymphoid-primed multipotent progenitors JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27542215 #FOAvip Zbtb1 is a transcription factor that prevents DNA damage and p53-mediated apoptosis in replicating immune progenitors, affecting lymphoid as well as myeloid development when hematopoietic progenitors are in competition in mixed bone marrow chimeras. However, Zbtb1-deficient mice do not have an apparent myeloid deficiency. We report here that Zbtb1-deficient lymphoid-primed multipotent progenitors (LMPPs) are biased to develop towards the myeloid fate in detriment of lymphoid development, contributing to the apparent unaffected myeloid development. Zbtb1 expression was maintained during lymphoid development of LMPP cells but downregulated during myeloid development. Deficiency of Zbtb1 in LMPP cells was sufficient to direct a myeloid fate in lymphoid-inducing conditions and in the absence of myeloid cytokines as shown by upregulation of a myeloid gene signature and the generation of myeloid cells in vitro. Finally, biased myeloid differentiation of Zbtb1-deficient LMPP cells was not due to increased p53-dependent apoptosis as it was not reverted by transgenic Bcl2 expression or p53 deficiency. Altogether, our results show that Zbtb1 expression prevents activation of a default myeloid program in LMPP cells, ensuring the generation of lymphoid cells. Twit Text FOAVip Zbtb1 prevents default myeloid differentiation of lymphoid-primed multipotent progenitors ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27542215 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27542215 #FOAvip English Wikipedia <ref>{{Cite pmid|27542215}}</ref> Zbtb1 prevents default myeloid differentiation of lymphoid-primed multipotent progenitors #MMPMID27542215 Zhang X; Lu Y; Cao X; Zhen T; Kovalovsky D Oncotarget 2016[Sep]; 7 (37): 58768-78 PMID27542215show ga Zbtb1 is a transcription factor that prevents DNA damage and p53-mediated apoptosis in replicating immune progenitors, affecting lymphoid as well as myeloid development when hematopoietic progenitors are in competition in mixed bone marrow chimeras. However, Zbtb1-deficient mice do not have an apparent myeloid deficiency. We report here that Zbtb1-deficient lymphoid-primed multipotent progenitors (LMPPs) are biased to develop towards the myeloid fate in detriment of lymphoid development, contributing to the apparent unaffected myeloid development. Zbtb1 expression was maintained during lymphoid development of LMPP cells but downregulated during myeloid development. Deficiency of Zbtb1 in LMPP cells was sufficient to direct a myeloid fate in lymphoid-inducing conditions and in the absence of myeloid cytokines as shown by upregulation of a myeloid gene signature and the generation of myeloid cells in vitro. Finally, biased myeloid differentiation of Zbtb1-deficient LMPP cells was not due to increased p53-dependent apoptosis as it was not reverted by transgenic Bcl2 expression or p53 deficiency. Altogether, our results show that Zbtb1 expression prevents activation of a default myeloid program in LMPP cells, ensuring the generation of lymphoid cells. äZbtb1 prevents default myeloid differentiation of lymphoid-primed mult(epmc).pdf DeepDyve Pubget Overpricing