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10.1098/rsfs.2016.0151 http://scihub22266oqcxt.onion/10.1098/rsfs.2016.0151 C5311910!5311910!28382206     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Interface+Focus 2017 ; 7 (2): ä Nephropedia Template TP {{tp|p=28382206|t=2017. Using chemical biology to assess and modulate mitochondria: progress and challenges |pdf=|usr=}}{{28382206}} gab.com Text Using chemical biology to assess and modulate mitochondria: progress and challenges JO: Interface Focus http://www.kidney.de/pget.php?&tw=1&pmid=28382206 #FOAvip Our understanding of the role of mitochondria in biomedical sciences has expanded considerably over the past decade. In addition to their well-known metabolic roles, mitochondrial are also central to signalling for various processes through the generation of signals such as ROS and metabolites that affect cellular homeostasis, as well as other processes such as cell death and inflammation. Thus, mitochondrial function and dysfunction are central to the health and fate of the cell. Consequently, there is considerable interest in better understanding and assessing the many roles of mitochondria. Furthermore, there is also a growing realization that mitochondrial are a promising drug target in a wide range of pathologies. The application of interdisciplinary approaches at the interface between chemistry and biology are opening up new opportunities to understand mitochondrial function and in assessing the role of the organelle in biology. This work and the experience thus gained are leading to the development of new classes of therapies. Here, we overview the progress that has been made to date on exploring the chemical biology of the organelle and then focus on future challenges and opportunities that face this rapidly developing field. Twit Text FOAVip Using chemical biology to assess and modulate mitochondria: progress and challenges ????Interface Focus http://www.kidney.de/pget.php?&tw=1&pmid=28382206 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28382206 #FOAvip English Wikipedia <ref>{{Cite pmid|28382206}}</ref> Using chemical biology to assess and modulate mitochondria: progress and challenges #MMPMID28382206 Logan A; Murphy MP Interface Focus 2017[Apr]; 7 (2): ä PMID28382206show ga Our understanding of the role of mitochondria in biomedical sciences has expanded considerably over the past decade. In addition to their well-known metabolic roles, mitochondrial are also central to signalling for various processes through the generation of signals such as ROS and metabolites that affect cellular homeostasis, as well as other processes such as cell death and inflammation. Thus, mitochondrial function and dysfunction are central to the health and fate of the cell. Consequently, there is considerable interest in better understanding and assessing the many roles of mitochondria. Furthermore, there is also a growing realization that mitochondrial are a promising drug target in a wide range of pathologies. The application of interdisciplinary approaches at the interface between chemistry and biology are opening up new opportunities to understand mitochondrial function and in assessing the role of the organelle in biology. This work and the experience thus gained are leading to the development of new classes of therapies. Here, we overview the progress that has been made to date on exploring the chemical biology of the organelle and then focus on future challenges and opportunities that face this rapidly developing field. äUsing chemical biology to assess and modulate mitochondria: progress a(epmc).pdf DeepDyve Pubget Overpricing