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10.1098/rsfs.2016.0109 http://scihub22266oqcxt.onion/10.1098/rsfs.2016.0109 C5311906!5311906!28382202     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Interface+Focus 2017 ; 7 (2): ä Nephropedia Template TP {{tp|p=28382202|t=2017. Mitochondria-targeted metformins: anti-tumour and redox signalling mechanisms |pdf=|usr=}}{{28382202}} gab.com Text Mitochondria-targeted metformins: anti-tumour and redox signalling mechanisms JO: Interface Focus http://www.kidney.de/pget.php?&tw=1&pmid=28382202 #FOAvip Reports suggest that metformin exerts anti-cancer effects in diabetic individuals with pancreatic cancer. Thus, metformin is currently being repurposed as a potential drug in cancer treatment. Studies indicate that potent metformin analogues are required in cancer treatment because of the low bioavailability of metformin in humans at conventional antidiabetic doses. We proposed that improved mitochondrial targeting of metformin by attaching a positively charged lipophilic triphenylphosphonium group will result in a new class of mitochondria-targeted metformin analogues with significantly enhanced anti-tumour potential. Using this approach, we synthesized various mitochondria-targeted metformin analogues with different alkyl chain lengths. Results indicate that the antiproliferative effects increased with increasing alkyl chain lengths (100-fold to 1000-fold). The lead compound, mito-metformin10, potently inhibited mitochondrial respiration through inhibition of complex I, stimulation of superoxide and hydrogen peroxide formation and activation of AMPK. When used in combination with ionizing radiation, mito-metformin10 acted as a radiosensitizer of pancreatic cancer cells. Because of the 1000-fold-higher potency of mitochondria-targeted metformin10, therapeutically effective plasma concentrations likely can be achieved in cancer patients. Twit Text FOAVip Mitochondria-targeted metformins: anti-tumour and redox signalling mechanisms ????Interface Focus http://www.kidney.de/pget.php?&tw=1&pmid=28382202 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28382202 #FOAvip English Wikipedia <ref>{{Cite pmid|28382202}}</ref> Mitochondria-targeted metformins: anti-tumour and redox signalling mechanisms #MMPMID28382202 Kalyanaraman B; Cheng G; Hardy M; Ouari O; Sikora A; Zielonka J; Dwinell M Interface Focus 2017[Apr]; 7 (2): ä PMID28382202show ga Reports suggest that metformin exerts anti-cancer effects in diabetic individuals with pancreatic cancer. Thus, metformin is currently being repurposed as a potential drug in cancer treatment. Studies indicate that potent metformin analogues are required in cancer treatment because of the low bioavailability of metformin in humans at conventional antidiabetic doses. We proposed that improved mitochondrial targeting of metformin by attaching a positively charged lipophilic triphenylphosphonium group will result in a new class of mitochondria-targeted metformin analogues with significantly enhanced anti-tumour potential. Using this approach, we synthesized various mitochondria-targeted metformin analogues with different alkyl chain lengths. Results indicate that the antiproliferative effects increased with increasing alkyl chain lengths (100-fold to 1000-fold). The lead compound, mito-metformin10, potently inhibited mitochondrial respiration through inhibition of complex I, stimulation of superoxide and hydrogen peroxide formation and activation of AMPK. When used in combination with ionizing radiation, mito-metformin10 acted as a radiosensitizer of pancreatic cancer cells. Because of the 1000-fold-higher potency of mitochondria-targeted metformin10, therapeutically effective plasma concentrations likely can be achieved in cancer patients. äMitochondria-targeted metformins: anti-tumour and redox signalling mec(epmc).pdf DeepDyve Pubget Overpricing