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10.18632/oncotarget.11191 http://scihub22266oqcxt.onion/10.18632/oncotarget.11191 C5308763!5308763!27517159     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2016 ; 7 (38): 62754-66 Nephropedia Template TP {{tp|p=27517159|t=2016. Technical challenges in the isolation and analysis of circulating tumor cells |pdf=|usr=}}{{27517159}} gab.com Text Technical challenges in the isolation and analysis of circulating tumor cells JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27517159 #FOAvip Increasing evidence suggests that cancer cells display dynamic molecular changes in response to systemic therapy. Circulating tumor cells (CTCs) in the peripheral blood represent a readily available source of cancer cells with which to measure this dynamic process. To date, a large number of strategies to isolate and characterize CTCs have been described. These techniques, however, each have unique limitations in their ability to sensitively and specifically detect these rare cells. In this review we focus on the technical limitations and pitfalls of the most common CTC isolation and detection strategies. Additionally, we emphasize the difficulties in correctly classifying rare cells as CTCs using common biomarkers. As for assays developed in the future, the first step must be a uniform and clear definition of the criteria for assigning an object as a CTC based on disease-specific biomarkers. Twit Text FOAVip Technical challenges in the isolation and analysis of circulating tumor cells ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27517159 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27517159 #FOAvip English Wikipedia <ref>{{Cite pmid|27517159}}</ref> Technical challenges in the isolation and analysis of circulating tumor cells #MMPMID27517159 van der Toom EE; Verdone JE; Gorin MA; Pienta KJ Oncotarget 2016[Sep]; 7 (38): 62754-66 PMID27517159show ga Increasing evidence suggests that cancer cells display dynamic molecular changes in response to systemic therapy. Circulating tumor cells (CTCs) in the peripheral blood represent a readily available source of cancer cells with which to measure this dynamic process. To date, a large number of strategies to isolate and characterize CTCs have been described. These techniques, however, each have unique limitations in their ability to sensitively and specifically detect these rare cells. In this review we focus on the technical limitations and pitfalls of the most common CTC isolation and detection strategies. Additionally, we emphasize the difficulties in correctly classifying rare cells as CTCs using common biomarkers. As for assays developed in the future, the first step must be a uniform and clear definition of the criteria for assigning an object as a CTC based on disease-specific biomarkers. äTechnical challenges in the isolation and analysis of circulating tumo(epmc).pdf DeepDyve Pubget Overpricing