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10.18632/oncotarget.11324 http://scihub22266oqcxt.onion/10.18632/oncotarget.11324 C5308701!5308701!27542280     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2016 ; 7 (38): 61930-44 Nephropedia Template TP {{tp|p=27542280|t=2016. The cytokine-cosmc signaling axis upregulates the tumor-associated carbohydrate antigen Tn |pdf=|usr=}}{{27542280}} gab.com Text The cytokine-cosmc signaling axis upregulates the tumor-associated carbohydrate antigen Tn JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27542280 #FOAvip Tn antigen (GalNAc-?-O-Ser/Thr), a mucin-type O-linked glycan, is a well-established cell surface marker for tumors and its elevated levels have been correlated with cancer progression and prognosis. There are also reports that Tn is elevated in inflammatory tissues. However, the molecular mechanism for its elevated levels in cancer and inflammation is unclear. In the current studies, we have explored the possibility that cytokines may be one of the common regulatory molecules for elevated Tn levels in both cancer and inflammation. We showed that the Tn level is elevated by the conditioned media of HrasG12V-transformed-BEAS-2B cells. Similarly, the conditioned media obtained from LPS-stimulated monocytes also elevated Tn levels in primary human gingival fibroblasts, suggesting the involvement of cytokines and/or other soluble factors. Indeed, purified inflammatory cytokines such as TNF-? and IL-6 up-regulated Tn levels in gingival fibroblasts. Furthermore, TNF-? was shown to down-regulate the COSMC gene as evidenced by reduced levels of the COSMC mRNA and protein, as well as hypermethylation of the CpG islands of the COSMC gene promoter. Since Cosmc, a chaperone for T-synthase, is known to negatively regulate Tn levels, our results suggest elevated Tn levels in cancer and inflammation may be commonly regulated by the cytokine-Cosmc signaling axis. Twit Text FOAVip The cytokine-cosmc signaling axis upregulates the tumor-associated carbohydrate antigen Tn ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27542280 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27542280 #FOAvip English Wikipedia <ref>{{Cite pmid|27542280}}</ref> The cytokine-cosmc signaling axis upregulates the tumor-associated carbohydrate antigen Tn #MMPMID27542280 Ho CW; Lin CY; Liaw YW; Chiang HL; Chin YT; Huang RL; Lai HC; Hsu YW; Kuo PJ; Chen CE; Lin HY; Whang-Peng J; Nieh S; Fu E; Liu LF; Hwang J Oncotarget 2016[Sep]; 7 (38): 61930-44 PMID27542280show ga Tn antigen (GalNAc-?-O-Ser/Thr), a mucin-type O-linked glycan, is a well-established cell surface marker for tumors and its elevated levels have been correlated with cancer progression and prognosis. There are also reports that Tn is elevated in inflammatory tissues. However, the molecular mechanism for its elevated levels in cancer and inflammation is unclear. In the current studies, we have explored the possibility that cytokines may be one of the common regulatory molecules for elevated Tn levels in both cancer and inflammation. We showed that the Tn level is elevated by the conditioned media of HrasG12V-transformed-BEAS-2B cells. Similarly, the conditioned media obtained from LPS-stimulated monocytes also elevated Tn levels in primary human gingival fibroblasts, suggesting the involvement of cytokines and/or other soluble factors. Indeed, purified inflammatory cytokines such as TNF-? and IL-6 up-regulated Tn levels in gingival fibroblasts. Furthermore, TNF-? was shown to down-regulate the COSMC gene as evidenced by reduced levels of the COSMC mRNA and protein, as well as hypermethylation of the CpG islands of the COSMC gene promoter. Since Cosmc, a chaperone for T-synthase, is known to negatively regulate Tn levels, our results suggest elevated Tn levels in cancer and inflammation may be commonly regulated by the cytokine-Cosmc signaling axis. äThe cytokine-cosmc signaling axis upregulates the tumor-associated car(epmc).pdf DeepDyve Pubget Overpricing