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10.3389/fgene.2017.00014 http://scihub22266oqcxt.onion/10.3389/fgene.2017.00014 C5306129!5306129!28261262     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Genet 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28261262|t=2017. The Evolutionary Relationship between Alternative Splicing and Gene Duplication |pdf=|usr=}}{{28261262}} gab.com Text The Evolutionary Relationship between Alternative Splicing and Gene Duplication JO: Front Genet http://www.kidney.de/pget.php?&tw=1&pmid=28261262 #FOAvip The protein diversity that exists today has resulted from various evolutionary processes. It is well known that gene duplication (GD) along with the accumulation of mutations are responsible, among other factors, for an increase in the number of different proteins. The gene structure in eukaryotes requires the removal of non-coding sequences, introns, to produce mature mRNAs. This process, known as cis-splicing, referred to here as splicing, is regulated by several factors which can lead to numerous splicing arrangements, commonly designated as alternative splicing (AS). AS, producing several transcripts isoforms form a single gene, also increases the protein diversity. However, the evolution and manner for increasing protein variation differs between AS and GD. An important question is how are patterns of AS affected after a GD event. Here, we review the current knowledge of AS and GD, focusing on their evolutionary relationship. These two processes are now considered the main contributors to the increasing protein diversity and therefore their relationship is a relevant, yet understudied, area of evolutionary study. Twit Text FOAVip The Evolutionary Relationship between Alternative Splicing and Gene Duplication ????Front Genet http://www.kidney.de/pget.php?&tw=1&pmid=28261262 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28261262 #FOAvip English Wikipedia <ref>{{Cite pmid|28261262}}</ref> The Evolutionary Relationship between Alternative Splicing and Gene Duplication #MMPMID28261262 Iñiguez LP; Hernández G Front Genet 2017[]; 8 (ä): ä PMID28261262show ga The protein diversity that exists today has resulted from various evolutionary processes. It is well known that gene duplication (GD) along with the accumulation of mutations are responsible, among other factors, for an increase in the number of different proteins. The gene structure in eukaryotes requires the removal of non-coding sequences, introns, to produce mature mRNAs. This process, known as cis-splicing, referred to here as splicing, is regulated by several factors which can lead to numerous splicing arrangements, commonly designated as alternative splicing (AS). AS, producing several transcripts isoforms form a single gene, also increases the protein diversity. However, the evolution and manner for increasing protein variation differs between AS and GD. An important question is how are patterns of AS affected after a GD event. Here, we review the current knowledge of AS and GD, focusing on their evolutionary relationship. These two processes are now considered the main contributors to the increasing protein diversity and therefore their relationship is a relevant, yet understudied, area of evolutionary study. äThe Evolutionary Relationship between Alternative Splicing and Gene Du(epmc).pdf DeepDyve Pubget Overpricing