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2014 ; 4
(2
): 454-484
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Mechanisms Underlying Cytotoxicity Induced by Engineered Nanomaterials: A Review
of In Vitro Studies
#MMPMID28344232
Nogueira DR
; Mitjans M
; Rolim CM
; Vinardell MP
Nanomaterials (Basel)
2014[Jun]; 4
(2
): 454-484
PMID28344232
show ga
Engineered nanomaterials are emerging functional materials with technologically
interesting properties and a wide range of promising applications, such as drug
delivery devices, medical imaging and diagnostics, and various other industrial
products. However, concerns have been expressed about the risks of such materials
and whether they can cause adverse effects. Studies of the potential hazards of
nanomaterials have been widely performed using cell models and a range of in
vitro approaches. In the present review, we provide a comprehensive and critical
literature overview on current in vitro toxicity test methods that have been
applied to determine the mechanisms underlying the cytotoxic effects induced by
the nanostructures. The small size, surface charge, hydrophobicity and high
adsorption capacity of nanomaterial allow for specific interactions within cell
membrane and subcellular organelles, which in turn could lead to cytotoxicity
through a range of different mechanisms. Finally, aggregating the given
information on the relationships of nanomaterial cytotoxic responses with an
understanding of its structure and physicochemical properties may promote the
design of biologically safe nanostructures.