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Infant fungal communities: current knowledge and research opportunities #MMPMID28190400
Ward TL; Knights D; Gale CA
BMC Med 2017[]; 15 (ä): ä PMID28190400show ga
The microbes colonizing the infant gastrointestinal tract have been implicated in later-life disease states such as allergies and obesity. Recently, the medical research community has begun to realize that very early colonization events may be most impactful on future health, with the presence of key taxa required for proper immune and metabolic development. However, most studies to date have focused on bacterial colonization events and have left out fungi, a clinically important sub-population of the microbiota. A number of recent findings indicate the importance of host-associated fungi (the mycobiota) in adult and infant disease states, including acute infections, allergies, and metabolism, making characterization of early human mycobiota an important frontier of medical research. This review summarizes the current state of knowledge with a focus on factors influencing infant mycobiota development and associations between early fungal exposures and health outcomes. We also propose next steps for infant fungal mycobiome research, including longitudinal studies of mother?infant pairs while monitoring long-term health outcomes, further exploration of bacterium?fungus interactions, and improved methods and databases for mycobiome quantitation.