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Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Curr+Cardiol+Rev 2016 ; 12 (4): 324-9 Nephropedia Template TP
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Anti-Thrombotic Effects of Statins in Acute Coronary Syndromes: At ?the Intersection of Thrombosis, Inflammation, and Platelet-Leukocyte ?Interactions #MMPMID27142048
Sexton T; Wallace EL; Smyth SS
Curr Cardiol Rev 2016[Nov]; 12 (4): 324-9 PMID27142048show ga
HMG CoA reductase inhibitors, or statins, are standard of care for preventing cardiovascular disease in at-risk populations. Statins are a well-established therapy proven to reduce long-term cardiovascular mortality and morbidity for prevention of secondary cardiovascular events and have become guideline-recommended therapy following acute myocardial infarction. Emerging data from clinical trials over the last decade indicates that statin therapy may provide broad beneficial effects beyond their primary lipid lowering mechanisms. In coronary heart disease, statins have demonstrated a unique ability to target several cellular pathways, which appear to play an underappreciated role in acute inflammation and subsequent thrombosis. Herein, we review the potential mechanisms where statins may act as antithrombotic agents in the setting of acute coronary syndromes and discuss the clinical implications of these findings.