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10.1038/srep42285 http://scihub22266oqcxt.onion/10.1038/srep42285 C5304227!5304227 !28205568     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28205568 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (ä): 42285 Nephropedia Template TP {{tp|p=28205568 |t=2017. Luman contributes to brefeldin A-induced prion protein gene expression by interacting with the ERSE26 element |pdf=|usr=}}{{28205568 }} gab.com Text Luman contributes to brefeldin A-induced prion protein gene expression by interacting with the ERSE26 element JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28205568 #FOAvip The cellular prion protein (PrP) is essential for transmissible prion diseases, but its exact physiological function remains unclear. Better understanding the regulation of the human prion protein gene (PRNP) expression can provide insight into this elusive function. Spliced XBP1 (sXBP1) was recently shown to mediate endoplasmic reticulum (ER) stress-induced PRNP expression. In this manuscript, we identify Luman, a ubiquitous, non-canonical unfolded protein response (UPR), as a novel regulator of ER stress-induced PRNP expression. Luman activity was transcriptionally and proteolytically activated by the ER stressing drug brefeldin A (BFA) in human neurons, astrocytes, and breast cancer MCF-7 cells. Over-expression of active cleaved Luman (?Luman) increased PrP levels, while siRNA-mediated Luman silencing decreased BFA-induced PRNP expression. Site-directed mutagenesis and chromatin immunoprecipitation demonstrated that ?Luman regulates PRNP expression by interacting with the ER stress response element 26 (ERSE26). Co-over-expression and siRNA-mediated silencing experiments showed that sXBP1 and ?Luman both up-regulate ER stress-induced PRNP expression. Attempts to understand the function of PRNP up-regulation by Luman excluded a role in atorvastatin-induced neuritogenesis, ER-associated degradation, or proteasomal inhibition-induced cell death. Overall, these results refine our understanding of ER stress-induced PRNP expression and function. Twit Text FOAVip Luman contributes to brefeldin A-induced prion protein gene expression by interacting with the ERSE26 element ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28205568 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28205568 #FOAvip English Wikipedia <ref>{{Cite pmid|28205568 }}</ref> Luman contributes to brefeldin A-induced prion protein gene expression by interacting with the ERSE26 element #MMPMID28205568 Déry MA ; LeBlanc AC Sci Rep 2017[Feb]; 7 (ä): 42285 PMID28205568 show ga The cellular prion protein (PrP) is essential for transmissible prion diseases, but its exact physiological function remains unclear. Better understanding the regulation of the human prion protein gene (PRNP) expression can provide insight into this elusive function. Spliced XBP1 (sXBP1) was recently shown to mediate endoplasmic reticulum (ER) stress-induced PRNP expression. In this manuscript, we identify Luman, a ubiquitous, non-canonical unfolded protein response (UPR), as a novel regulator of ER stress-induced PRNP expression. Luman activity was transcriptionally and proteolytically activated by the ER stressing drug brefeldin A (BFA) in human neurons, astrocytes, and breast cancer MCF-7 cells. Over-expression of active cleaved Luman (?Luman) increased PrP levels, while siRNA-mediated Luman silencing decreased BFA-induced PRNP expression. Site-directed mutagenesis and chromatin immunoprecipitation demonstrated that ?Luman regulates PRNP expression by interacting with the ER stress response element 26 (ERSE26). Co-over-expression and siRNA-mediated silencing experiments showed that sXBP1 and ?Luman both up-regulate ER stress-induced PRNP expression. Attempts to understand the function of PRNP up-regulation by Luman excluded a role in atorvastatin-induced neuritogenesis, ER-associated degradation, or proteasomal inhibition-induced cell death. Overall, these results refine our understanding of ER stress-induced PRNP expression and function. |Animals [MESH] |Atorvastatin/pharmacology [MESH] |Base Sequence [MESH] |Brefeldin A/*pharmacology [MESH] |Caspase 3/metabolism [MESH] |Caspase 7/metabolism [MESH] |Cell Line [MESH] |Cyclic AMP Response Element-Binding Protein/genetics/*metabolism [MESH] |Endoplasmic Reticulum Stress/drug effects/*genetics [MESH] |Endoplasmic Reticulum-Associated Degradation/drug effects [MESH] |Gene Expression Regulation/*drug effects [MESH] |Humans [MESH] |Mice [MESH] |Neurites/drug effects/metabolism [MESH] |Neurogenesis/drug effects [MESH] |Oligopeptides/pharmacology [MESH] |Prealbumin/metabolism [MESH] |Prion Proteins/*genetics/metabolism [MESH] |Promoter Regions, Genetic/genetics [MESH] |Response Elements/*genetics [MESH] |Substrate Specificity/drug effects [MESH] |Transcription, Genetic/drug effects [MESH] |Up-Regulation/genetics [MESH]Luman contributes to brefeldin A-induced prion protein gene expression(epmc).pdf DeepDyve Pubget Overpricing