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10.1126/science.aag3180 http://scihub22266oqcxt.onion/10.1126/science.aag3180 C5303695!5303695!27940577     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27940577&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2017 ; 355 (6321): 170-3 Nephropedia Template TP {{tp|p=27940577|t=2017. Pyocyanin degradation by a tautomerizing demethylase inhibits Pseudomonas aeruginosa biofilms |pdf=|usr=}}{{27940577}} gab.com Text Pyocyanin degradation by a tautomerizing demethylase inhibits Pseudomonas aeruginosa biofilms JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=27940577 #FOAvip The opportunistic pathogen Pseudomonas aeruginosa produces colorful redox-active metabolites called phenazines, which underpin biofilm development, virulence and clinical outcomes. Though phenazines exist in many forms, the best studied is pyocyanin. Here, we describe pyocyanin demethylase (PodA), a hitherto uncharacterized protein that oxidizes the pyocyanin methyl group to formaldehyde and reduces the pyrazine ring via an unusual tautomerizing demethylation reaction. Treatment with PodA disrupts P. aeruginosa biofilm formation similarly to DNase, suggesting interference with the pyocyanin-dependent release of extracellular DNA into the matrix. PodA-dependent pyocyanin demethylation also restricts established biofilm aggregate populations experiencing anoxic conditions. Together, these results show that modulating extracellular redox-active metabolites can influence the fitness of biofilms. Twit Text FOAVip Pyocyanin degradation by a tautomerizing demethylase inhibits Pseudomonas aeruginosa biofilms ????Science http://www.kidney.de/pget.php?&tw=1&pmid=27940577 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27940577 #FOAvip English Wikipedia <ref>{{Cite pmid|27940577}}</ref> Pyocyanin degradation by a tautomerizing demethylase inhibits Pseudomonas aeruginosa biofilms #MMPMID27940577 Costa KC; Glasser NR; Conway SJ; Newman DK Science 2017[Jan]; 355 (6321): 170-3 PMID27940577show ga The opportunistic pathogen Pseudomonas aeruginosa produces colorful redox-active metabolites called phenazines, which underpin biofilm development, virulence and clinical outcomes. Though phenazines exist in many forms, the best studied is pyocyanin. Here, we describe pyocyanin demethylase (PodA), a hitherto uncharacterized protein that oxidizes the pyocyanin methyl group to formaldehyde and reduces the pyrazine ring via an unusual tautomerizing demethylation reaction. Treatment with PodA disrupts P. aeruginosa biofilm formation similarly to DNase, suggesting interference with the pyocyanin-dependent release of extracellular DNA into the matrix. PodA-dependent pyocyanin demethylation also restricts established biofilm aggregate populations experiencing anoxic conditions. Together, these results show that modulating extracellular redox-active metabolites can influence the fitness of biofilms. äPyocyanin degradation by a tautomerizing demethylase inhibits Pseudomo(epmc).pdf DeepDyve Pubget Overpricing