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suck abstract from ncbi


10.1158/2159-8290.CD-16-0860

http://scihub22266oqcxt.onion/10.1158/2159-8290.CD-16-0860
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C5300099!5300099!28003236
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suck abstract from ncbi


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pmid28003236      Cancer+Discov 2017 ; 7 (1): 20-37
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  • Targeting DNA Repair in Cancer: Beyond PARP Inhibitors #MMPMID28003236
  • Brown JS; O?Carrigan B; Jackson SP; Yap TA
  • Cancer Discov 2017[Jan]; 7 (1): 20-37 PMID28003236show ga
  • Germline aberrations in critical DNA repair and DNA-damage response (DDR) genes cause cancer predisposition, while various tumors harbor somatic mutations causing defective DDR/DNA repair. The concept of synthetic lethality can be exploited in such malignancies, as exemplified by approval of poly(ADP-ribose) polymerase inhibitors for treating BRCA1/2 mutated ovarian cancers. Herein, we detail how cellular DDR processes engage various proteins that sense DNA damage, initiate signaling pathways to promote cell cycle checkpoint activation, trigger apoptosis and coordinate DNA repair. We focus on novel therapeutic strategies targeting promising DDR targets and discuss challenges of patient selection and the development of rational drug combinations.
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