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10.1073/pnas.1612920114 http://scihub22266oqcxt.onion/10.1073/pnas.1612920114 C5293015!5293015!28096371     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (5): 1117-22 Nephropedia Template TP {{tp|p=28096371|t=2017. COX2/mPGES1/PGE2 pathway regulates PD-L1 expression in tumor-associated macrophages and myeloid-derived suppressor cells |pdf=|usr=}}{{28096371}} gab.com Text COX2/mPGES1/PGE2 pathway regulates PD-L1 expression in tumor-associated macrophages and myeloid-derived suppressor cells JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28096371 #FOAvip Programmed cell death protein ligand 1 (PD-L1)?expressing cells mediate tumor evasion from immune system by suppressing activated T lymphocytes. A bioactive lipid prostaglandin E2 (PGE2) formed from arachidonic acid by COXs and PGE2 synthases (PGESs) facilitates both cancer inflammation and immune suppression. Here, we show that tumor cells can induce PD-L1 expression in bone marrow?derived cells by affecting PGE2 metabolism in hematopoietic cells. The tumor-induced PD-L1 expression was limited to the myeloid cell lineage and, specifically, to the macrophages and myeloid-derived suppressor cells. Collectively, the obtained results demonstrate that selective inhibition of PGE2-forming enzymes COX2, murine PGES1, or genetic overexpression of PGE2-degrading enzyme 15-hydroxyprostaglandin dehydrogenase could provide a novel approach to regulate both PGE2 levels and PD-L1 expression in cancer, thus alleviating the immune suppression and stimulating antitumor immune response. Twit Text FOAVip COX2/mPGES1/PGE2 pathway regulates PD-L1 expression in tumor-associated macrophages and myeloid-derived suppressor cells ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28096371 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28096371 #FOAvip English Wikipedia <ref>{{Cite pmid|28096371}}</ref> COX2/mPGES1/PGE2 pathway regulates PD-L1 expression in tumor-associated macrophages and myeloid-derived suppressor cells #MMPMID28096371 Prima V; Kaliberova LN; Kaliberov S; Curiel DT; Kusmartsev S Proc Natl Acad Sci U S A 2017[Jan]; 114 (5): 1117-22 PMID28096371show ga Programmed cell death protein ligand 1 (PD-L1)?expressing cells mediate tumor evasion from immune system by suppressing activated T lymphocytes. A bioactive lipid prostaglandin E2 (PGE2) formed from arachidonic acid by COXs and PGE2 synthases (PGESs) facilitates both cancer inflammation and immune suppression. Here, we show that tumor cells can induce PD-L1 expression in bone marrow?derived cells by affecting PGE2 metabolism in hematopoietic cells. The tumor-induced PD-L1 expression was limited to the myeloid cell lineage and, specifically, to the macrophages and myeloid-derived suppressor cells. Collectively, the obtained results demonstrate that selective inhibition of PGE2-forming enzymes COX2, murine PGES1, or genetic overexpression of PGE2-degrading enzyme 15-hydroxyprostaglandin dehydrogenase could provide a novel approach to regulate both PGE2 levels and PD-L1 expression in cancer, thus alleviating the immune suppression and stimulating antitumor immune response. äCOX2/mPGES1/PGE2 pathway regulates PD-L1 expression in tumor-associate(epmc).pdf DeepDyve Pubget Overpricing