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10.1530/JOE-16-0425 http://scihub22266oqcxt.onion/10.1530/JOE-16-0425 C5292977!5292977!27913573     free     free     free       J+Endocrinol 2016 ; 232 (2): 351-62 Nephropedia Template TP {{tp|p=27913573|t=2016. Thyroid hormones induce browning of white fat |pdf=|usr=}}{{27913573}} gab.com Text Thyroid hormones induce browning of white fat JO: J Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=27913573 #FOAvip The canonical view about the effect of thyroid hormones (THs) on thermogenesis assumes that the hypothalamus acts merely as a modulator of the sympathetic outflow on brown adipose tissue (BAT). Recent data have challenged that vision by demonstrating that THs act on the ventromedial nucleus of the hypothalamus (VMH) to inhibit AMP-activated protein kinase (AMPK), which regulates the thermogenic program in BAT, leading to increased thermogenesis and weight loss. Current data have shown that in addition to activation of brown fat, the browning of white adipose tissue (WAT) might also be an important thermogenic mechanism. However, the possible central effects of THs on the browning of white fat remain unclear. Here, we show that 3,3?,5,5? tetraiodothyroxyne (T4)-induced hyperthyroidism promotes a marked browning of WAT. Of note, central or VMH-specific administration of 3,3?,5-triiodothyronine (T3) recapitulates that effect. The specific genetic activation of hypothalamic AMPK in the VMH reversed the central effect of T3 on browning. Finally, we also showed that the expression of browning genes in human WAT correlates with serum T4. Overall, these data indicate that THs induce browning of WAT and that this mechanism is mediated via the central effects of THs on energy balance. Twit Text FOAVip Thyroid hormones induce browning of white fat ????J Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=27913573 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27913573 #FOAvip English Wikipedia <ref>{{Cite pmid|27913573}}</ref> Thyroid hormones induce browning of white fat #MMPMID27913573 Martínez-Sánchez N; Moreno-Navarrete JM; Contreras C; Rial-Pensado E; Fernř J; Nogueiras R; Diéguez C; Fernández-Real JM; López M J Endocrinol 2016[Dec]; 232 (2): 351-62 PMID27913573show ga The canonical view about the effect of thyroid hormones (THs) on thermogenesis assumes that the hypothalamus acts merely as a modulator of the sympathetic outflow on brown adipose tissue (BAT). Recent data have challenged that vision by demonstrating that THs act on the ventromedial nucleus of the hypothalamus (VMH) to inhibit AMP-activated protein kinase (AMPK), which regulates the thermogenic program in BAT, leading to increased thermogenesis and weight loss. Current data have shown that in addition to activation of brown fat, the browning of white adipose tissue (WAT) might also be an important thermogenic mechanism. However, the possible central effects of THs on the browning of white fat remain unclear. Here, we show that 3,3?,5,5? tetraiodothyroxyne (T4)-induced hyperthyroidism promotes a marked browning of WAT. Of note, central or VMH-specific administration of 3,3?,5-triiodothyronine (T3) recapitulates that effect. The specific genetic activation of hypothalamic AMPK in the VMH reversed the central effect of T3 on browning. Finally, we also showed that the expression of browning genes in human WAT correlates with serum T4. Overall, these data indicate that THs induce browning of WAT and that this mechanism is mediated via the central effects of THs on energy balance. äThyroid hormones induce browning of white fat (epmc).pdf DeepDyve Pubget Overpricing