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10.1038/nri.2016.93 http://scihub22266oqcxt.onion/10.1038/nri.2016.93 C5291318!5291318!27616589     free     free     free       Nat+Rev+Immunol 2016 ; 16 (11): 702-14 Nephropedia Template TP {{tp|p=27616589|t=2016. PI3K? and primary immunodeficiencies |pdf=|usr=}}{{27616589}} gab.com Text PI3K and primary immunodeficiencies JO: Nat Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27616589 #FOAvip Primary immunodeficiencies are inherited disorders of the immune system, often caused by the mutation of genes required for lymphocyte development and activation. Recently, several studies have identified gain-of-function mutations in the phosphoinositide 3-kinase (PI3K) genes PIK3CD (which encodes p110?) and PIK3R1 (which encodes p85?) that cause a combined immunodeficiency syndrome, referred to as activated PI3K? syndrome (APDS) or p110?-activating mutation causing senescent T cells, lymphadenopathy and immunodeficiency (PASLI). Paradoxically, both loss-of-function and gain-of-function mutations that affect these genes lead to immunosuppression, albeit via different mechanisms. Here, we review the roles of PI3K? in adaptive immunity, describe the clinical manifestations and mechanisms of disease in APDS and highlight new insights into PI3K? gleaned from these patients, as well as implications of these findings for clinical therapy. Twit Text FOAVip PI3K and primary immunodeficiencies ????Nat Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27616589 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27616589 #FOAvip English Wikipedia <ref>{{Cite pmid|27616589}}</ref> PI3K? and primary immunodeficiencies #MMPMID27616589 Lucas CL; Chandra A; Nejentsev S; Condliffe AM; Okkenhaug K Nat Rev Immunol 2016[Nov]; 16 (11): 702-14 PMID27616589show ga Primary immunodeficiencies are inherited disorders of the immune system, often caused by the mutation of genes required for lymphocyte development and activation. Recently, several studies have identified gain-of-function mutations in the phosphoinositide 3-kinase (PI3K) genes PIK3CD (which encodes p110?) and PIK3R1 (which encodes p85?) that cause a combined immunodeficiency syndrome, referred to as activated PI3K? syndrome (APDS) or p110?-activating mutation causing senescent T cells, lymphadenopathy and immunodeficiency (PASLI). Paradoxically, both loss-of-function and gain-of-function mutations that affect these genes lead to immunosuppression, albeit via different mechanisms. Here, we review the roles of PI3K? in adaptive immunity, describe the clinical manifestations and mechanisms of disease in APDS and highlight new insights into PI3K? gleaned from these patients, as well as implications of these findings for clinical therapy. äPI3K? and primary immunodeficiencies (epmc).pdf DeepDyve Pubget Overpricing