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10.1016/j.biomaterials.2016.05.055 http://scihub22266oqcxt.onion/10.1016/j.biomaterials.2016.05.055 C5290709!5290709 !27343468     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27343468 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biomaterials 2016 ; 102 (ä): 209-19 Nephropedia Template TP {{tp|p=27343468 |t=2016. Painting factor H onto mesenchymal stem cells protects the cells from complement- and neutrophil-mediated damage |pdf=|usr=}}{{27343468 }} gab.com Text Painting factor H onto mesenchymal stem cells protects the cells from complement- and neutrophil-mediated damage JO: Biomaterials http://www.kidney.de/pget.php?&tw=1&pmid=27343468 #FOAvip Mesenchymal stem cells (MSCs) are undergoing intensive testing in clinical trials as a promising new therapy for many inflammatory diseases and for regenerative medicine, but further optimization of current MSC-based therapies is required. In this study, we found that in addition to direct complement-mediated attack through the assembly of membrane attack complexes (MACs) that we and others have recently reported, of the released complement activation products, C5a, but not C3a, activates neutrophils in the blood to further damage MSCs through oxidative burst. In addition, we have developed a simple method for painting factor H, a native complement inhibitor, onto MSCs to locally inhibit complement activation on MSCs. MSCs painted with factor H are protected from both MAC- and neutrophil-mediated attack and are significantly more effective in inhibiting antigen-specific T cell responses than the mock-painted MSCs both in vitro and in vivo. Twit Text FOAVip Painting factor H onto mesenchymal stem cells protects the cells from complement- and neutrophil-mediated damage ????Biomaterials http://www.kidney.de/pget.php?&tw=1&pmid=27343468 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27343468 #FOAvip English Wikipedia <ref>{{Cite pmid|27343468 }}</ref> Painting factor H onto mesenchymal stem cells protects the cells from complement- and neutrophil-mediated damage #MMPMID27343468 Li Y ; Qiu W ; Zhang L ; Fung J ; Lin F Biomaterials 2016[Sep]; 102 (ä): 209-19 PMID27343468 show ga Mesenchymal stem cells (MSCs) are undergoing intensive testing in clinical trials as a promising new therapy for many inflammatory diseases and for regenerative medicine, but further optimization of current MSC-based therapies is required. In this study, we found that in addition to direct complement-mediated attack through the assembly of membrane attack complexes (MACs) that we and others have recently reported, of the released complement activation products, C5a, but not C3a, activates neutrophils in the blood to further damage MSCs through oxidative burst. In addition, we have developed a simple method for painting factor H, a native complement inhibitor, onto MSCs to locally inhibit complement activation on MSCs. MSCs painted with factor H are protected from both MAC- and neutrophil-mediated attack and are significantly more effective in inhibiting antigen-specific T cell responses than the mock-painted MSCs both in vitro and in vivo. |Animals [MESH] |Cells, Cultured [MESH] |Complement Activation/*drug effects [MESH] |Complement Factor H/immunology/*pharmacology [MESH] |Complement System Proteins/immunology [MESH] |Humans [MESH] |Mesenchymal Stem Cell Transplantation/*methods [MESH] |Mesenchymal Stem Cells/*immunology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Neutrophils/*drug effects/immunology [MESH] |Receptor, Anaphylatoxin C5a/immunology [MESH]Painting factor H onto mesenchymal stem cells protects the cells from (epmc).pdf DeepDyve Pubget Overpricing