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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Auton+Neurosci
2017 ; 204
(ä): 17-24
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Eppur Si Muove: The dynamic nature of physiological control of renal blood flow
by the renal sympathetic nerves
#MMPMID27514571
Schiller AM
; Pellegrino PR
; Zucker IH
Auton Neurosci
2017[May]; 204
(ä): 17-24
PMID27514571
show ga
Tubuloglomerular feedback and the myogenic response are widely appreciated as
important regulators of renal blood flow, but the role of the sympathetic nervous
system in physiological renal blood flow control remains controversial. Where
classic studies using static measures of renal blood flow failed, dynamic
approaches have succeeded in demonstrating sympathetic control of renal blood
flow under normal physiological conditions. This review focuses on transfer
function analysis of renal pressure-flow, which leverages the physical
relationship between blood pressure and flow to assess the underlying vascular
control mechanisms. Studies using this approach indicate that the renal nerves
are important in the rapid regulation of the renal vasculature. Animals with
intact renal innervation show a sympathetic signature in the frequency range
associated with sympathetic vasomotion that is eliminated by renal denervation.
In conscious rabbits, this sympathetic signature exerts vasoconstrictive,
baroreflex control of renal vascular conductance, matching well with the
rhythmic, baroreflex-influenced control of renal sympathetic nerve activity and
complementing findings from other studies employing dynamic approaches to study
renal sympathetic vascular control. In this light, classic studies reporting that
nerve stimulation and renal denervation do not affect static measures of renal
blood flow provide evidence for the strength of renal autoregulation rather than
evidence against physiological renal sympathetic control of renal blood flow.
Thus, alongside tubuloglomerular feedback and the myogenic response, renal
sympathetic outflow should be considered an important physiological regulator of
renal blood flow. Clinically, renal sympathetic vasomotion may be important for
solving the problems facing the field of therapeutic renal denervation.