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10.1111/cei.12897 http://scihub22266oqcxt.onion/10.1111/cei.12897 C5290247!5290247 !27997991     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27997991 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27997991 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Clin+Exp+Immunol 2017 ; 187 (3 ): 441-454 Nephropedia Template TP {{tp|p=27997991 |t=2017. Decreased frequencies and impaired functions of the CD31(+) subpopulation in T(reg) cells associated with decreased FoxP3 expression and enhanced T(reg) cell defects in patients with coronary heart disease |pdf=|usr=}}{{27997991 }} gab.com Text Decreased frequencies and impaired functions of the CD31(+) subpopulation in T(reg) cells associated with decreased FoxP3 expression and enhanced T(reg) cell defects in patients with coronary heart disease JO: Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27997991 #FOAvip Coronary heart disease (CHD) is one of the most common types of organ lesions caused by atherosclerosis, in which CD4(+) CD25(+) forkhead box protein 3 (FoxP3(+) ) regulatory T cells (T(reg) ) play an atheroprotective role. However, T(reg) cell numbers are decreased and their functions are impaired in atherosclerosis; the underlying mechanisms remain unclear. CD31 plays an important part in T cell response and contributes to maintaining T cell tolerance. The immunomodulatory effects of CD31 are also implicated in atherosclerosis. In this study, we found that decreased frequencies of the CD31(+) subpopulation in T(reg) cells (CD31(+) Tr cells) correlated positively with decreased FoxP3 expression in CHD patients. Cell culture in vitro demonstrated CD31(+) Tr cells maintaining stable FoxP3 expression after activation and exhibited enhanced proliferation and immunosuppression compared with the CD31(-) subpopulation in T(reg) cells (CD31(-) Tr cells). We also confirmed impaired secretion of transforming growth factor (TGF)-?1 and interleukin (IL)-10 in CD31(+) Tr cells of CHD patients. Further analysis revealed reduced phospho-SHP2 (associated with CD31 activation) and phospho-signal transducer and activator of transcription-5 (STAT-5) (associated with FoxP3 transcription) levels in CD31(+) Tr cells of CHD patients, suggesting that decreased FoxP3 expression in CD31(+) Tr cells might be because of attenuated SHP2 and STAT-5 activation. These data indicate that decreased frequencies and impaired functions of the CD31(+) Tr subpopulation associated with decreased FoxP3 expression give rise, at least in part, to T(reg) cell defects in CHD patients. Our findings emphasize the important role of the CD31(+) Tr subpopulation in maintaining T(reg) cell normal function and may provide a novel explanation for impaired immunoregulation of T(reg) cells in CHD. Twit Text FOAVip Decreased frequencies and impaired functions of the CD31(+) subpopulation in T(reg) cells associated with decreased FoxP3 expression and enhanced T(reg) cell defects in patients with coronary heart disease ????Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27997991 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27997991 #FOAvip English Wikipedia <ref>{{Cite pmid|27997991 }}</ref> Decreased frequencies and impaired functions of the CD31(+) subpopulation in T(reg) cells associated with decreased FoxP3 expression and enhanced T(reg) cell defects in patients with coronary heart disease #MMPMID27997991 Huang L ; Zheng Y ; Yuan X ; Ma Y ; Xie G ; Wang W ; Chen H ; Shen L Clin Exp Immunol 2017[Mar]; 187 (3 ): 441-454 PMID27997991 show ga Coronary heart disease (CHD) is one of the most common types of organ lesions caused by atherosclerosis, in which CD4(+) CD25(+) forkhead box protein 3 (FoxP3(+) ) regulatory T cells (T(reg) ) play an atheroprotective role. However, T(reg) cell numbers are decreased and their functions are impaired in atherosclerosis; the underlying mechanisms remain unclear. CD31 plays an important part in T cell response and contributes to maintaining T cell tolerance. The immunomodulatory effects of CD31 are also implicated in atherosclerosis. In this study, we found that decreased frequencies of the CD31(+) subpopulation in T(reg) cells (CD31(+) Tr cells) correlated positively with decreased FoxP3 expression in CHD patients. Cell culture in vitro demonstrated CD31(+) Tr cells maintaining stable FoxP3 expression after activation and exhibited enhanced proliferation and immunosuppression compared with the CD31(-) subpopulation in T(reg) cells (CD31(-) Tr cells). We also confirmed impaired secretion of transforming growth factor (TGF)-?1 and interleukin (IL)-10 in CD31(+) Tr cells of CHD patients. Further analysis revealed reduced phospho-SHP2 (associated with CD31 activation) and phospho-signal transducer and activator of transcription-5 (STAT-5) (associated with FoxP3 transcription) levels in CD31(+) Tr cells of CHD patients, suggesting that decreased FoxP3 expression in CD31(+) Tr cells might be because of attenuated SHP2 and STAT-5 activation. These data indicate that decreased frequencies and impaired functions of the CD31(+) Tr subpopulation associated with decreased FoxP3 expression give rise, at least in part, to T(reg) cell defects in CHD patients. Our findings emphasize the important role of the CD31(+) Tr subpopulation in maintaining T(reg) cell normal function and may provide a novel explanation for impaired immunoregulation of T(reg) cells in CHD. |Cells, Cultured [MESH] |Coronary Artery Disease/*immunology/metabolism [MESH] |Female [MESH] |Forkhead Transcription Factors/*metabolism [MESH] |Humans [MESH] |Immune Tolerance/immunology [MESH] |Interleukin-10/metabolism [MESH] |Leukocytes, Mononuclear/immunology/metabolism [MESH] |Male [MESH] |Middle Aged [MESH] |Platelet Endothelial Cell Adhesion Molecule-1/*metabolism [MESH] |Protein Tyrosine Phosphatase, Non-Receptor Type 11/metabolism [MESH] |STAT5 Transcription Factor/metabolism [MESH] |T-Lymphocytes, Regulatory/*immunology/metabolism [MESH]Decreased frequencies and impaired functions of the CD31(+) subpopulat(epmc).pdf DeepDyve Pubget Overpricing