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10.1111/cei.12898 http://scihub22266oqcxt.onion/10.1111/cei.12898 C5290232!5290232 !27921303     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27921303 &cmd=llinks): Failed to open stream: HTTP request failed! 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Eosinophils from eosinophilic oesophagitis patients have T cell suppressive capacity and express FOXP3 |pdf=|usr=}}{{27921303 }} gab.com Text Eosinophils from eosinophilic oesophagitis patients have T cell suppressive capacity and express FOXP3 JO: Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27921303 #FOAvip Eosinophilic esophagitis (EoE) is an antigen-driven T cell-mediated chronic inflammatory disease where food and environmental antigens are thought to have a role. Human eosinophils express the immunoregulatory protein galectin-10 and have T cell suppressive capacity similar to regulatory T cells (T(regs) ). We hypothesized that one function of eosinophils in EoE might be to regulate the T cell-driven inflammation in the oesophagus. This was tested by evaluating the suppressive capacity of eosinophils isolated from the blood of adult EoE patients in a mixed lymphocyte reaction. In addition, eosinophilic expression of forkhead box protein 3 (FOXP3), the canonical transcription factor of T(regs) , was determined by conventional and imaging flow cytometry, quantitative polymerase chain reaction (qPCR), confocal microscopy and immunoblotting. It was found that blood eosinophils from EoE patients had T cell suppressive capacity, and that a fraction of the eosinophils expressed FOXP3. A comparison of EoE eosinophils with healthy control eosinophils indicated that the patients' eosinophils had inferior suppressive capacity. Furthermore, a higher percentage of the EoE eosinophils expressed FOXP3 protein compared with the healthy eosinophils, and they also had higher FOXP3 protein and mRNA levels. FOXP3 was found in the cytosol and nucleus of the eosinophils from both the patients and healthy individuals, contrasting with the strict nuclear localization of FOXP3 in T(regs) . To conclude, these findings suggest that the immunoregulatory function of eosinophils may be impaired in EoE. Twit Text FOAVip Eosinophils from eosinophilic oesophagitis patients have T cell suppressive capacity and express FOXP3 ????Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27921303 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27921303 #FOAvip English Wikipedia <ref>{{Cite pmid|27921303 }}</ref> Eosinophils from eosinophilic oesophagitis patients have T cell suppressive capacity and express FOXP3 #MMPMID27921303 Lingblom C ; Wallander J ; Ingelsten M ; Bergquist H ; Bove M ; Saalman R ; Welin A ; Wennerås C Clin Exp Immunol 2017[Mar]; 187 (3 ): 455-465 PMID27921303 show ga Eosinophilic esophagitis (EoE) is an antigen-driven T cell-mediated chronic inflammatory disease where food and environmental antigens are thought to have a role. Human eosinophils express the immunoregulatory protein galectin-10 and have T cell suppressive capacity similar to regulatory T cells (T(regs) ). We hypothesized that one function of eosinophils in EoE might be to regulate the T cell-driven inflammation in the oesophagus. This was tested by evaluating the suppressive capacity of eosinophils isolated from the blood of adult EoE patients in a mixed lymphocyte reaction. In addition, eosinophilic expression of forkhead box protein 3 (FOXP3), the canonical transcription factor of T(regs) , was determined by conventional and imaging flow cytometry, quantitative polymerase chain reaction (qPCR), confocal microscopy and immunoblotting. It was found that blood eosinophils from EoE patients had T cell suppressive capacity, and that a fraction of the eosinophils expressed FOXP3. A comparison of EoE eosinophils with healthy control eosinophils indicated that the patients' eosinophils had inferior suppressive capacity. Furthermore, a higher percentage of the EoE eosinophils expressed FOXP3 protein compared with the healthy eosinophils, and they also had higher FOXP3 protein and mRNA levels. FOXP3 was found in the cytosol and nucleus of the eosinophils from both the patients and healthy individuals, contrasting with the strict nuclear localization of FOXP3 in T(regs) . To conclude, these findings suggest that the immunoregulatory function of eosinophils may be impaired in EoE. |Adolescent [MESH] |Adult [MESH] |Aged [MESH] |Eosinophilic Esophagitis/*immunology [MESH] |Eosinophils/*immunology [MESH] |Female [MESH] |Forkhead Transcription Factors/*immunology [MESH] |Humans [MESH] |Inflammation/immunology [MESH] |Leukocyte Count/methods [MESH] |Male [MESH] |Middle Aged [MESH] |T-Lymphocytes, Regulatory/*immunology [MESH]Eosinophils from eosinophilic oesophagitis patients have T cell suppre(epmc).pdf DeepDyve Pubget Overpricing