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10.1158/0008-5472.CAN-16-0559 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-16-0559 C5290198!5290198!27651315     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Res 2016 ; 76 (22): 6555-67 Nephropedia Template TP {{tp|p=27651315|t=2016. BRD4 regulates breast cancer dissemination through Jagged1/Notch1 signaling |pdf=|usr=}}{{27651315}} gab.com Text BRD4 regulates breast cancer dissemination through Jagged1/Notch1 signaling JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=27651315 #FOAvip The Bromodomain and ExtraTerminal (BET) proteins are epigenetic ?readers? of acetylated histones in chromatin and have been identified as promising therapeutic targets in diverse cancers. However, it remains unclear how individual family members participate in cancer progression, and small molecule inhibitors such as JQ1 can target functionally independent BET proteins. Here we report a signaling pathway involving BRD4 and the ligand/receptor pair Jagged1/Notch1 that sustains triple-negative breast cancer migration and invasion. BRD4, but not BRD2 or BRD3, regulated Jagged1 expression and Notch1 signaling. BRD4-selective knockdown suppressed Notch1 activity and impeded breast cancer migration and invasion. BRD4 was required for interleukin-6-stimulated, Notch1-induced migration and invasion, coupling microenvironment inflammation with cancer propagation. Moreover, in patients, BRD4 and Jagged1 expression positively correlated with the presence of distant metastases. These results identify a BRD4/Jagged1/Notch1 signaling pathway that is critical for dissemination of triple-negative breast cancer. Twit Text FOAVip BRD4 regulates breast cancer dissemination through Jagged1/Notch1 signaling ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=27651315 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27651315 #FOAvip English Wikipedia <ref>{{Cite pmid|27651315}}</ref> BRD4 regulates breast cancer dissemination through Jagged1/Notch1 signaling #MMPMID27651315 Andrieu G; Tran AH; Strissel KJ; Denis GV Cancer Res 2016[Nov]; 76 (22): 6555-67 PMID27651315show ga The Bromodomain and ExtraTerminal (BET) proteins are epigenetic ?readers? of acetylated histones in chromatin and have been identified as promising therapeutic targets in diverse cancers. However, it remains unclear how individual family members participate in cancer progression, and small molecule inhibitors such as JQ1 can target functionally independent BET proteins. Here we report a signaling pathway involving BRD4 and the ligand/receptor pair Jagged1/Notch1 that sustains triple-negative breast cancer migration and invasion. BRD4, but not BRD2 or BRD3, regulated Jagged1 expression and Notch1 signaling. BRD4-selective knockdown suppressed Notch1 activity and impeded breast cancer migration and invasion. BRD4 was required for interleukin-6-stimulated, Notch1-induced migration and invasion, coupling microenvironment inflammation with cancer propagation. Moreover, in patients, BRD4 and Jagged1 expression positively correlated with the presence of distant metastases. These results identify a BRD4/Jagged1/Notch1 signaling pathway that is critical for dissemination of triple-negative breast cancer. äBRD4 regulates breast cancer dissemination through Jagged1/Notch1 sign(epmc).pdf DeepDyve Pubget Overpricing