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10.3349/ymj.2017.58.2.401 http://scihub22266oqcxt.onion/10.3349/ymj.2017.58.2.401 C5290021!5290021 !28120572     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28120572 &cmd=llinks): Failed to open stream: HTTP request failed! 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The Level of Serum and Urinary Nephrin in Normal Pregnancy and Pregnancy with Subsequent Preeclampsia |pdf=|usr=}}{{28120572 }} gab.com Text The Level of Serum and Urinary Nephrin in Normal Pregnancy and Pregnancy with Subsequent Preeclampsia JO: Yonsei Med J http://www.kidney.de/pget.php?&tw=1&pmid=28120572 #FOAvip PURPOSE: The aim of this study was to evaluate serum and urinary nephrin levels of normal pregnancy to establish a standard reference value and to compare them with patients who subsequently developed preeclampsia (PE). MATERIALS AND METHODS: In this prospective study, 117 healthy singleton pregnancies were enrolled between 6 to 20 weeks of gestation at 2 participating medical centers during October 2010 to March 2012. Urine and serum samples were collected at the time of enrollment, each trimester, and at 4 to 6 weeks postpartum. Enzyme-linked immunosorbent assay for nephrin was performed and samples from patients who subsequently developed PE were compared to the normal patients. RESULTS: Of 117 patients initially enrolled, 99 patients delivered at the study centers and of those patients, 12 (12.1%) developed PE at a median gestational age of 34?? weeks (range 29??-36??). In the normal patients (n=68), serum nephrin level decreased and urinary nephrin level increased during the latter of pregnancy. In 12 patients who subsequently developed PE, a significant rise in the 3rd trimester serum and urinary nephrin levels, compared to the controls, was observed (p<0.001), and this increase occurred 9 days prior to the onset of clinical disease. CONCLUSION: As the onset of PE was preceded by the rise in the serum and urinary nephrin in comparison to normal pregnancy, serum and urinary nephrin may be a useful predictive marker of PE. Twit Text FOAVip The Level of Serum and Urinary Nephrin in Normal Pregnancy and Pregnancy with Subsequent Preeclampsia ????Yonsei Med J http://www.kidney.de/pget.php?&tw=1&pmid=28120572 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28120572 #FOAvip English Wikipedia <ref>{{Cite pmid|28120572 }}</ref> The Level of Serum and Urinary Nephrin in Normal Pregnancy and Pregnancy with Subsequent Preeclampsia #MMPMID28120572 Jung YJ ; Cho HY ; Cho S ; Kim YH ; Jeon JD ; Kim YJ ; Lee S ; Park J ; Kim HY ; Park YW ; Kwon JY Yonsei Med J 2017[Mar]; 58 (2 ): 401-406 PMID28120572 show ga PURPOSE: The aim of this study was to evaluate serum and urinary nephrin levels of normal pregnancy to establish a standard reference value and to compare them with patients who subsequently developed preeclampsia (PE). MATERIALS AND METHODS: In this prospective study, 117 healthy singleton pregnancies were enrolled between 6 to 20 weeks of gestation at 2 participating medical centers during October 2010 to March 2012. Urine and serum samples were collected at the time of enrollment, each trimester, and at 4 to 6 weeks postpartum. Enzyme-linked immunosorbent assay for nephrin was performed and samples from patients who subsequently developed PE were compared to the normal patients. RESULTS: Of 117 patients initially enrolled, 99 patients delivered at the study centers and of those patients, 12 (12.1%) developed PE at a median gestational age of 34?? weeks (range 29??-36??). In the normal patients (n=68), serum nephrin level decreased and urinary nephrin level increased during the latter of pregnancy. In 12 patients who subsequently developed PE, a significant rise in the 3rd trimester serum and urinary nephrin levels, compared to the controls, was observed (p<0.001), and this increase occurred 9 days prior to the onset of clinical disease. CONCLUSION: As the onset of PE was preceded by the rise in the serum and urinary nephrin in comparison to normal pregnancy, serum and urinary nephrin may be a useful predictive marker of PE. |Adult [MESH] |Biomarkers/blood/urine [MESH] |Case-Control Studies [MESH] |Enzyme-Linked Immunosorbent Assay [MESH] |Female [MESH] |Gestational Age [MESH] |Humans [MESH] |Membrane Proteins/*blood/*urine [MESH] |Pre-Eclampsia/blood/*etiology/urine [MESH] |Pregnancy [MESH] |Pregnancy Proteins [MESH] |Pregnancy Trimester, Third/blood/urine [MESH] |Prospective Studies [MESH]The Level of Serum and Urinary Nephrin in Normal Pregnancy and Pregnan(epmc).pdf DeepDyve Pubget Overpricing