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2017 ; 58
(2
): 290-295
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Nobori-Biolimus-Eluting Stents versus Resolute Zotarolimus-Eluting Stents in
Patients Undergoing Coronary Intervention: A Propensity Score Matching
#MMPMID28120558
Tantawy A
; Ahn CM
; Shin DH
; Kim JS
; Kim BK
; Ko YG
; Choi D
; Jang Y
; Hong MK
Yonsei Med J
2017[Mar]; 58
(2
): 290-295
PMID28120558
show ga
PURPOSE: To compare the 1-year outcomes of a durable polymer Zotarolimus-eluting
stent (ZES) versus a biodegradable polymer Biolimus-eluting stent (BES) in
patients undergoing percutaneous coronary intervention. MATERIALS AND METHODS: A
total of 2083 patients from 2 different registries, 1125 treated with BES in
NOBORI registry and 858 received ZES in CONSTANT registry were included in this
study. Clinical outcomes were compared with the use of propensity score matching
(PSM). The primary endpoint was a composite of major adverse cardiovascular and
cerebrovascular events (MACCEs) including cardiac death, myocardial infarction,
clinically driven target lesion revascularization and stroke. Secondary end
points were individual components of MACCEs as well as the incidence of stent
thrombosis at 1-year follow-up. RESULTS: After PSM, 699 matched pairs of patients
(n=1398) showed no significant difference between BES and ZES in the risk of
composite MACCEs at 1 year (2.6% vs. 1.7%; p=0.36). Cardiac death was not
statistically different between groups (0.7% vs. 0.4%, p=0.73). Target lesion
revascularization rate was also similar between BES and ZES (1.1% vs. 0.7%,
p=0.579). Non-Q wave myocardial infarction, as well as target-vessel
revascularization rate, was similar between the two groups (0.14% for BES and
0.72% for ZES). Both stent types were excellent with no cases of stent thrombosis
and rate of Q wave myocardial infarction reported during the follow-up period.
CONCLUSION: In this cohort of patients treated with BES or ZES, the rate of
MACCEs at 1 year was low and significantly not different between both groups.