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10.1038/ni.3643 http://scihub22266oqcxt.onion/10.1038/ni.3643 C5289297!5289297!27992404     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2017 ; 18 (2): 152-60 Nephropedia Template TP {{tp|p=27992404|t=2017. VGLL3-regulated gene network as a promoter of sex biased autoimmune diseases |pdf=|usr=}}{{27992404}} gab.com Text VGLL3-regulated gene network as a promoter of sex biased autoimmune diseases JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27992404 #FOAvip Autoimmune diseases affect 7.5% of the U.S. population, and are among the leading causes of death and disability. A striking feature of many autoimmune diseases is their increased prevalence in females, but the underlying mechanisms have remained unclear. Using high-resolution global transcriptome analyses we demonstrate a female-biased molecular signature associated with autoimmune disease susceptibility, and linked to extensive sex-dependent, co-expression networks. This signature was independent of biological age and sex-hormone regulation, and regulated by the transcription factor VGLL3, which also had a strong female biased expression. On a genome-wide level, VGLL3-regulated genes had a strong association with multiple autoimmune diseases including lupus, scleroderma and Sjögren?s syndrome and had a prominent transcriptomic overlap with inflammatory processes in cutaneous lupus. These results identify VGLL3-regulated gene network as a novel inflammatory pathway promoting female-biased autoimmunity, they demonstrate the importance of studying immunological processes in females and males separately, and open up new avenues for therapeutic development. Twit Text FOAVip VGLL3-regulated gene network as a promoter of sex biased autoimmune diseases ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27992404 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27992404 #FOAvip English Wikipedia <ref>{{Cite pmid|27992404}}</ref> VGLL3-regulated gene network as a promoter of sex biased autoimmune diseases #MMPMID27992404 Liang Y; Tsoi LC; Xing X; Beamer MA; Swindell WR; Sarkar MK; Berthier CC; Stuart PE; Harms PW; Nair RP; Elder JT; Voorhees JJ; Kahlenberg JM; Gudjonsson JE Nat Immunol 2017[Feb]; 18 (2): 152-60 PMID27992404show ga Autoimmune diseases affect 7.5% of the U.S. population, and are among the leading causes of death and disability. A striking feature of many autoimmune diseases is their increased prevalence in females, but the underlying mechanisms have remained unclear. Using high-resolution global transcriptome analyses we demonstrate a female-biased molecular signature associated with autoimmune disease susceptibility, and linked to extensive sex-dependent, co-expression networks. This signature was independent of biological age and sex-hormone regulation, and regulated by the transcription factor VGLL3, which also had a strong female biased expression. On a genome-wide level, VGLL3-regulated genes had a strong association with multiple autoimmune diseases including lupus, scleroderma and Sjögren?s syndrome and had a prominent transcriptomic overlap with inflammatory processes in cutaneous lupus. These results identify VGLL3-regulated gene network as a novel inflammatory pathway promoting female-biased autoimmunity, they demonstrate the importance of studying immunological processes in females and males separately, and open up new avenues for therapeutic development. äVGLL3-regulated gene network as a promoter of sex biased autoimmune di(epmc).pdf DeepDyve Pubget Overpricing