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10.1038/ni.3643 http://scihub22266oqcxt.onion/10.1038/ni.3643 C5289297!5289297 !27992404     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27992404 &cmd=llinks): Failed to open stream: HTTP request failed! 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A gene network regulated by the transcription factor VGLL3 as a promoter of sex-biased autoimmune diseases |pdf=|usr=}}{{27992404 }} gab.com Text A gene network regulated by the transcription factor VGLL3 as a promoter of sex-biased autoimmune diseases JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27992404 #FOAvip Autoimmune diseases affect 7.5% of the US population, and they are among the leading causes of death and disability. A notable feature of many autoimmune diseases is their greater prevalence in females than in males, but the underlying mechanisms of this have remained unclear. Through the use of high-resolution global transcriptome analyses, we demonstrated a female-biased molecular signature associated with susceptibility to autoimmune disease and linked this to extensive sex-dependent co-expression networks. This signature was independent of biological age and sex-hormone regulation and was regulated by the transcription factor VGLL3, which also had a strong female-biased expression. On a genome-wide level, VGLL3-regulated genes had a strong association with multiple autoimmune diseases, including lupus, scleroderma and Sjögren's syndrome, and had a prominent transcriptomic overlap with inflammatory processes in cutaneous lupus. These results identified a VGLL3-regulated network as a previously unknown inflammatory pathway that promotes female-biased autoimmunity. They demonstrate the importance of studying immunological processes in females and males separately and suggest new avenues for therapeutic development. Twit Text FOAVip A gene network regulated by the transcription factor VGLL3 as a promoter of sex-biased autoimmune diseases ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27992404 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27992404 #FOAvip English Wikipedia <ref>{{Cite pmid|27992404 }}</ref> A gene network regulated by the transcription factor VGLL3 as a promoter of sex-biased autoimmune diseases #MMPMID27992404 Liang Y ; Tsoi LC ; Xing X ; Beamer MA ; Swindell WR ; Sarkar MK ; Berthier CC ; Stuart PE ; Harms PW ; Nair RP ; Elder JT ; Voorhees JJ ; Kahlenberg JM ; Gudjonsson JE Nat Immunol 2017[Feb]; 18 (2 ): 152-160 PMID27992404 show ga Autoimmune diseases affect 7.5% of the US population, and they are among the leading causes of death and disability. A notable feature of many autoimmune diseases is their greater prevalence in females than in males, but the underlying mechanisms of this have remained unclear. Through the use of high-resolution global transcriptome analyses, we demonstrated a female-biased molecular signature associated with susceptibility to autoimmune disease and linked this to extensive sex-dependent co-expression networks. This signature was independent of biological age and sex-hormone regulation and was regulated by the transcription factor VGLL3, which also had a strong female-biased expression. On a genome-wide level, VGLL3-regulated genes had a strong association with multiple autoimmune diseases, including lupus, scleroderma and Sjögren's syndrome, and had a prominent transcriptomic overlap with inflammatory processes in cutaneous lupus. These results identified a VGLL3-regulated network as a previously unknown inflammatory pathway that promotes female-biased autoimmunity. They demonstrate the importance of studying immunological processes in females and males separately and suggest new avenues for therapeutic development. |*Gene Regulatory Networks [MESH] |*Sex Factors [MESH] |Adult [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Cells, Cultured [MESH] |Female [MESH] |Gene Expression Profiling [MESH] |Genetic Association Studies [MESH] |Genome-Wide Association Study [MESH] |Humans [MESH] |Keratinocytes/*physiology [MESH] |Lupus Erythematosus, Cutaneous/*genetics [MESH] |Male [MESH] |Middle Aged [MESH] |Quantitative Trait Loci [MESH] |Scleroderma, Systemic/*genetics [MESH] |Sjogren's Syndrome/*genetics [MESH] |Skin/*pathology [MESH] |Transcription Factors/genetics/*metabolism [MESH] |Transcriptome [MESH]A gene network regulated by the transcription factor VGLL3 as a promot(epmc).pdf DeepDyve Pubget Overpricing