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10.1101/gad.293837.116 http://scihub22266oqcxt.onion/10.1101/gad.293837.116 C5287114!5287114 !28108474     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28108474 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Genes+Dev 2017 ; 31 (1 ): 6-11 Nephropedia Template TP {{tp|p=28108474 |t=2017. The human initiator is a distinct and abundant element that is precisely positioned in focused core promoters |pdf=|usr=}}{{28108474 }} gab.com Text The human initiator is a distinct and abundant element that is precisely positioned in focused core promoters JO: Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=28108474 #FOAvip DNA sequence signals in the core promoter, such as the initiator (Inr), direct transcription initiation by RNA polymerase II. Here we show that the human Inr has the consensus of BBCA(+1)BW at focused promoters in which transcription initiates at a single site or a narrow cluster of sites. The analysis of 7678 focused transcription start sites revealed 40% with a perfect match to the Inr and 16% with a single mismatch outside of the CA(+1) core. TATA-like sequences are underrepresented in Inr promoters. This consensus is a key component of the DNA sequence rules that specify transcription initiation in humans. Twit Text FOAVip The human initiator is a distinct and abundant element that is precisely positioned in focused core promoters ????Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=28108474 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28108474 #FOAvip English Wikipedia <ref>{{Cite pmid|28108474 }}</ref> The human initiator is a distinct and abundant element that is precisely positioned in focused core promoters #MMPMID28108474 Vo Ngoc L ; Cassidy CJ ; Huang CY ; Duttke SH ; Kadonaga JT Genes Dev 2017[Jan]; 31 (1 ): 6-11 PMID28108474 show ga DNA sequence signals in the core promoter, such as the initiator (Inr), direct transcription initiation by RNA polymerase II. Here we show that the human Inr has the consensus of BBCA(+1)BW at focused promoters in which transcription initiates at a single site or a narrow cluster of sites. The analysis of 7678 focused transcription start sites revealed 40% with a perfect match to the Inr and 16% with a single mismatch outside of the CA(+1) core. TATA-like sequences are underrepresented in Inr promoters. This consensus is a key component of the DNA sequence rules that specify transcription initiation in humans. |*Transcription Initiation Site [MESH] |Conserved Sequence/genetics [MESH] |DNA Mutational Analysis [MESH] |Humans [MESH] |MCF-7 Cells [MESH] |Mutation [MESH] |Promoter Regions, Genetic/*genetics [MESH] |Sequence Homology, Nucleic Acid [MESH]The human initiator is a distinct and abundant element that is precise(epmc).pdf DeepDyve Pubget Overpricing