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10.1080/19336950.2016.1212141 http://scihub22266oqcxt.onion/10.1080/19336950.2016.1212141 C5279873!5279873!27414851     free     free     free       Channels+(Austin) 2017 ; 11 (1): 84-8 Nephropedia Template TP {{tp|p=27414851|t=2017. Role of STIM1 in the surface expression of SARAF |pdf=|usr=}}{{27414851}} gab.com Text Role of STIM1 in the surface expression of SARAF JO: Channels (Austin) http://www.kidney.de/pget.php?&tw=1&pmid=27414851 #FOAvip The store-operated Ca2+ entry-associated regulatory factor (SARAF), a protein expressed both in the endoplasmic reticulum and the plasma membrane, has been presented as a STIM1-interacting protein with the ability to modulate intracellular Ca2+ homeostasis. SARAF negatively modulates store-operated Ca2+ entry (SOCE) by preventing STIM1 spontaneous activation and regulating STIM1-Orai1 complex formation. In addition, SARAF is a negative regulator of Ca2+ entry through the arachidonate-regulated Ca2+ (ARC) channels. Here we explored the possible role of the surface expression of SARAF on the location of STIM1 in the plasma membrane. In NG115-401L cells, lacking a detectable expression of native STIM1, transfection with pHluorin-STIM1, which is able to translocate to the cell surface, enhances the plasma membrane location of SARAF as compared to cells transfected with YFP-STIM1, lacking the ability to translocate to the cell surface. These findings suggest that the surface location of SARAF is dependent on the expression of STIM1 in the plasma membrane. Twit Text FOAVip Role of STIM1 in the surface expression of SARAF ????Channels (Austin) http://www.kidney.de/pget.php?&tw=1&pmid=27414851 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27414851 #FOAvip English Wikipedia <ref>{{Cite pmid|27414851}}</ref> Role of STIM1 in the surface expression of SARAF #MMPMID27414851 Albarran L; Regodón S; Salido GM; Lopez JJ; Rosado JA Channels (Austin) 2017[]; 11 (1): 84-8 PMID27414851show ga The store-operated Ca2+ entry-associated regulatory factor (SARAF), a protein expressed both in the endoplasmic reticulum and the plasma membrane, has been presented as a STIM1-interacting protein with the ability to modulate intracellular Ca2+ homeostasis. SARAF negatively modulates store-operated Ca2+ entry (SOCE) by preventing STIM1 spontaneous activation and regulating STIM1-Orai1 complex formation. In addition, SARAF is a negative regulator of Ca2+ entry through the arachidonate-regulated Ca2+ (ARC) channels. Here we explored the possible role of the surface expression of SARAF on the location of STIM1 in the plasma membrane. In NG115-401L cells, lacking a detectable expression of native STIM1, transfection with pHluorin-STIM1, which is able to translocate to the cell surface, enhances the plasma membrane location of SARAF as compared to cells transfected with YFP-STIM1, lacking the ability to translocate to the cell surface. These findings suggest that the surface location of SARAF is dependent on the expression of STIM1 in the plasma membrane. äRole of STIM1 in the surface expression of SARAF (epmc).pdf DeepDyve Pubget Overpricing