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2015 ; 12
(3-4
): 243-59
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Novel Genetic Actors of Diabetes-Associated Microvascular Complications:
Retinopathy, Kidney Disease and Neuropathy
#MMPMID26859656
Davoudi S
; Sobrin L
Rev Diabet Stud
2015[Fal]; 12
(3-4
): 243-59
PMID26859656
show ga
Both type 1 and type 2 diabetes mellitus can lead to the common microvascular
complications of diabetic retinopathy, kidney disease, and neuropathy. Diabetic
patients do not universally develop these complications. Long duration of
diabetes and poor glycemic control explain a lot of the variability in the
development of microvascular complications, but not all. Genetic factors account
for some of the remaining variability because of the heritability and familial
clustering of these complications. There have been a large number of
investigations, including linkage studies, candidate gene studies, and
genome-wide association studies, all of which have sought to identify the
specific variants that increase susceptibility. For retinopathy, several
genome-wide association studies have been performed in small or midsize samples,
but no reproducible loci across the studies have been identified. For diabetic
kidney disease, genome-wide association studies in larger samples have been
performed, and loci for this complication are beginning to emerge. However,
validation of the existing discoveries, and further novel discoveries in larger
samples is ongoing. The amount of genetic research into diabetic neuropathy has
been very limited, and much is dedicated to the understanding of genetic risk
factors only. Collaborations that pool samples and aim to detect phenotype
classifications more precisely are promising avenues for a better explanation of
the genetics of diabetic microvascular complications.
|Diabetes Mellitus, Type 2/complications/*genetics
[MESH]
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