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10.1038/ni.3552 http://scihub22266oqcxt.onion/10.1038/ni.3552 C5257269!5257269!27595232     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2016 ; 17 (11): 1273-81 Nephropedia Template TP {{tp|p=27595232|t=2016. MUC1 modulates the tumor immune microenvironment through the engagement of Siglec-9 |pdf=|usr=}}{{27595232}} gab.com Text MUC1 modulates the tumor immune microenvironment through the engagement of Siglec-9 JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27595232 #FOAvip Siglec-9 is a sialic acid binding lectin predominantly expressed on myeloid cells. Aberrant glycosylation occurs in essentially all types of cancers resulting in increased sialylation. Thus when MUC1 is expressed on cancer cells it is decorated by multiple short, sialylated O-linked glycans (MUC1-ST). Here we show that this cancer-specific MUC1 glycoform could, through the engagement of Siglec-9, educate myeloid cells to release factors associated with tumor microenvironment determination and disease progression. Moreover MUC1-ST induced macrophages to display a TAM-like phenotype with increased expression of PD-L1. MUC1-ST binding to Siglec-9 did not activate SHP-1/2 but surprisingly induced calcium flux leading to MEK-ERK activation. This work defines a critical role for aberrantly glycosylated MUC1 and identifies an activating pathway following Siglec-9 engagement. Twit Text FOAVip MUC1 modulates the tumor immune microenvironment through the engagement of Siglec-9 ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27595232 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27595232 #FOAvip English Wikipedia <ref>{{Cite pmid|27595232}}</ref> MUC1 modulates the tumor immune microenvironment through the engagement of Siglec-9 #MMPMID27595232 Beatson R; Tajadura-Ortega V; Achkova D; Picco G; Tsourouktsoglou TD; Klausing S; Hillier M; Maher J; Noll T; Crocker PR; Taylor-Papadimitriou J; Burchell JM Nat Immunol 2016[Nov]; 17 (11): 1273-81 PMID27595232show ga Siglec-9 is a sialic acid binding lectin predominantly expressed on myeloid cells. Aberrant glycosylation occurs in essentially all types of cancers resulting in increased sialylation. Thus when MUC1 is expressed on cancer cells it is decorated by multiple short, sialylated O-linked glycans (MUC1-ST). Here we show that this cancer-specific MUC1 glycoform could, through the engagement of Siglec-9, educate myeloid cells to release factors associated with tumor microenvironment determination and disease progression. Moreover MUC1-ST induced macrophages to display a TAM-like phenotype with increased expression of PD-L1. MUC1-ST binding to Siglec-9 did not activate SHP-1/2 but surprisingly induced calcium flux leading to MEK-ERK activation. This work defines a critical role for aberrantly glycosylated MUC1 and identifies an activating pathway following Siglec-9 engagement. äMUC1 modulates the tumor immune microenvironment through the engagemen(epmc).pdf DeepDyve Pubget Overpricing