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10.1073/pnas.1614035114 http://scihub22266oqcxt.onion/10.1073/pnas.1614035114 C5255630!5255630!28049847     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (3): 580-5 Nephropedia Template TP {{tp|p=28049847|t=2017. Gpr132 sensing of lactate mediates tumor?macrophage interplay to promote breast cancer metastasis |pdf=|usr=}}{{28049847}} gab.com Text Gpr132 sensing of lactate mediates tumor macrophage interplay to promote breast cancer metastasis JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28049847 #FOAvip Metastasis is a major cause of cancer mortality. However, the regulation of this complex process remains poorly understood. Due to low oxygen supply and enhanced sugar metabolism, cancer cells releases lactate to create an acidic environment. We show that a membrane receptor on macrophages called G protein-coupled receptor 132 (Gpr132) can sense and respond to this lactate signal from cancer cells. As a result, macrophages alter their functions, which, in turn, stimulates cancer metastasis to distant organs. Consequently, loss of Gpr132 in mice inhibits breast cancer metastasis; lower Gpr132 expression in patients with breast cancer correlates with better metastasis-free survival. These findings uncover knowledge and potentially novel treatment for cancer metastasis. Twit Text FOAVip Gpr132 sensing of lactate mediates tumor macrophage interplay to promote breast cancer metastasis ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28049847 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28049847 #FOAvip English Wikipedia <ref>{{Cite pmid|28049847}}</ref> Gpr132 sensing of lactate mediates tumor?macrophage interplay to promote breast cancer metastasis #MMPMID28049847 Chen P; Zuo H; Xiong H; Kolar MJ; Chu Q; Saghatelian A; Siegwart DJ; Wan Y Proc Natl Acad Sci U S A 2017[Jan]; 114 (3): 580-5 PMID28049847show ga Metastasis is a major cause of cancer mortality. However, the regulation of this complex process remains poorly understood. Due to low oxygen supply and enhanced sugar metabolism, cancer cells releases lactate to create an acidic environment. We show that a membrane receptor on macrophages called G protein-coupled receptor 132 (Gpr132) can sense and respond to this lactate signal from cancer cells. As a result, macrophages alter their functions, which, in turn, stimulates cancer metastasis to distant organs. Consequently, loss of Gpr132 in mice inhibits breast cancer metastasis; lower Gpr132 expression in patients with breast cancer correlates with better metastasis-free survival. These findings uncover knowledge and potentially novel treatment for cancer metastasis. äGpr132 sensing of lactate mediates tumor?macrophage interplay to promo(epmc).pdf DeepDyve Pubget Overpricing