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10.1038/mi.2016.61 http://scihub22266oqcxt.onion/10.1038/mi.2016.61 C5250615!5250615!27435108     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mucosal+Immunol 2017 ; 10 (2): 341-51 Nephropedia Template TP {{tp|p=27435108|t=2017. Periostin regulates fibrocyte function to promote myofibroblast differentiation and lung fibrosis |pdf=|usr=}}{{27435108}} gab.com Text Periostin regulates fibrocyte function to promote myofibroblast differentiation and lung fibrosis JO: Mucosal Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27435108 #FOAvip Fibrocytes are circulating mesenchymal precursors (CD45+, col 1+) recruited to fibrotic areas. Fibrocytes secrete profibrotic mediators including periostin; a matricellular protein that regulates cellular interactions with extracellular matrix (ECM) components. In bleomycin-induced fibrosis, periostin deficiency in structural or hematopoietic cells limits development of pulmonary fibrosis. To determine if hematopoietic-derived fibrocytes might secrete soluble factors to activate structural myofibroblast differentiation, wild-type (WT) fibroblasts were treated with conditioned medium from fibrocytes isolated from bleomycin-treated WT or periostin?/? mice. After 24 hours we saw less ?-smooth muscle actin expression in cells treated with conditioned medium from periostin?/? fibrocytes. Adoptive transfer of WT fibrocytes augmented lung fibrosis to a greater extent than transfer of fibrocytes from periostin?/? mice. In vitro analysis of fibrocytes and fibroblasts isolated from WT and periostin ?/? mice treated with TGF?1 or periostin demonstrated co-regulation of mesenchymal activation and beta 1 integrin as a potential receptor for periostin on fibrocytes. Additionally, connective tissue growth factor (CTGF) mRNA expression was increased in fibrocytes treated with periostin whereas CTGF and lysl oxidase (LOX) mRNA expression was low in bleomycin-treated periostin?/? fibrocytes. These data suggest fibrocytes may augment bleomycin-induced fibrosis via secretion of periostin and other soluble factors that promote myofibroblast differentiation. Twit Text FOAVip Periostin regulates fibrocyte function to promote myofibroblast differentiation and lung fibrosis ????Mucosal Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27435108 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27435108 #FOAvip English Wikipedia <ref>{{Cite pmid|27435108}}</ref> Periostin regulates fibrocyte function to promote myofibroblast differentiation and lung fibrosis #MMPMID27435108 Ashley SL; Wilke CA; Kim KK; Moore BB Mucosal Immunol 2017[Mar]; 10 (2): 341-51 PMID27435108show ga Fibrocytes are circulating mesenchymal precursors (CD45+, col 1+) recruited to fibrotic areas. Fibrocytes secrete profibrotic mediators including periostin; a matricellular protein that regulates cellular interactions with extracellular matrix (ECM) components. In bleomycin-induced fibrosis, periostin deficiency in structural or hematopoietic cells limits development of pulmonary fibrosis. To determine if hematopoietic-derived fibrocytes might secrete soluble factors to activate structural myofibroblast differentiation, wild-type (WT) fibroblasts were treated with conditioned medium from fibrocytes isolated from bleomycin-treated WT or periostin?/? mice. After 24 hours we saw less ?-smooth muscle actin expression in cells treated with conditioned medium from periostin?/? fibrocytes. Adoptive transfer of WT fibrocytes augmented lung fibrosis to a greater extent than transfer of fibrocytes from periostin?/? mice. In vitro analysis of fibrocytes and fibroblasts isolated from WT and periostin ?/? mice treated with TGF?1 or periostin demonstrated co-regulation of mesenchymal activation and beta 1 integrin as a potential receptor for periostin on fibrocytes. Additionally, connective tissue growth factor (CTGF) mRNA expression was increased in fibrocytes treated with periostin whereas CTGF and lysl oxidase (LOX) mRNA expression was low in bleomycin-treated periostin?/? fibrocytes. These data suggest fibrocytes may augment bleomycin-induced fibrosis via secretion of periostin and other soluble factors that promote myofibroblast differentiation. äPeriostin regulates fibrocyte function to promote myofibroblast differ(epmc).pdf DeepDyve Pubget Overpricing