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10.1158/0008-5472.CAN-16-2301 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-16-2301 C5243833!5243833!28062403     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Res 2017 ; 77 (2): 227-33 Nephropedia Template TP {{tp|p=28062403|t=2017. Mutated Chromatin Regulatory Factors as Tumor Drivers in Cancer |pdf=|usr=}}{{28062403}} gab.com Text Mutated Chromatin Regulatory Factors as Tumor Drivers in Cancer JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=28062403 #FOAvip Genes encoding proteins which regulate chromatin structure and DNA modifications (i.e., chromatin regulatory factors, or CRFs) and genes encoding histone proteins harbor recurrent mutations in most human cancers. These mutations lead to modifications in tumor chromatin and DNA structure and an altered epigenetic state that contribute to tumorigenesis. Mutated CRFs have now been identified in most types of cancer, and are increasingly regarded as novel therapeutic targets. In this review, we discuss DNA alterations in CRFs and how these influence tumor chromatin structure and function, which in turn leads to tumorigenesis. We also discuss the clinical implications and review concepts of targeted treatments for these mutations. Continued research on CRF mutations will be critical for our future understanding of cancer biology and the development and implementation of novel cancer therapies. Twit Text FOAVip Mutated Chromatin Regulatory Factors as Tumor Drivers in Cancer ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=28062403 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28062403 #FOAvip English Wikipedia <ref>{{Cite pmid|28062403}}</ref> Mutated Chromatin Regulatory Factors as Tumor Drivers in Cancer #MMPMID28062403 Koschmann C; Nunez FJ; Mendez F; Brosnan-Cashman JA; Meeker A; Lowenstein PR; Castro MG Cancer Res 2017[Jan]; 77 (2): 227-33 PMID28062403show ga Genes encoding proteins which regulate chromatin structure and DNA modifications (i.e., chromatin regulatory factors, or CRFs) and genes encoding histone proteins harbor recurrent mutations in most human cancers. These mutations lead to modifications in tumor chromatin and DNA structure and an altered epigenetic state that contribute to tumorigenesis. Mutated CRFs have now been identified in most types of cancer, and are increasingly regarded as novel therapeutic targets. In this review, we discuss DNA alterations in CRFs and how these influence tumor chromatin structure and function, which in turn leads to tumorigenesis. We also discuss the clinical implications and review concepts of targeted treatments for these mutations. Continued research on CRF mutations will be critical for our future understanding of cancer biology and the development and implementation of novel cancer therapies. äMutated Chromatin Regulatory Factors as Tumor Drivers in Cancer (epmc).pdf DeepDyve Pubget Overpricing