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10.1152/ajpheart.00384.2016 http://scihub22266oqcxt.onion/10.1152/ajpheart.00384.2016 C5243209!5243209 !27591221     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27591221 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Am+J+Physiol+Heart+Circ+Physiol 2016 ; 311 (5 ): H1170-H1179 Nephropedia Template TP {{tp|p=27591221 |t=2016. Arterial baroreflex control of sympathetic nerve activity and heart rate in patients with type 2 diabetes |pdf=|usr=}}{{27591221 }} gab.com Text Arterial baroreflex control of sympathetic nerve activity and heart rate in patients with type 2 diabetes JO: Am J Physiol Heart Circ Physiol http://www.kidney.de/pget.php?&tw=1&pmid=27591221 #FOAvip Despite greater blood pressure reactivity to acute cardiovascular stressors and a higher prevalence of hypertension in type 2 diabetes (T2D) patients, limited information is available regarding arterial baroreflex (ABR) control in T2D. We hypothesized that ABR control of muscle sympathetic nerve activity (MSNA) and heart rate (HR) are attenuated in T2D patients. Seventeen T2D patients (50 ± 2 yr; 31 ± 1 kg/m(2)), 9 weight-matched controls (WM-CON, 46 ± 2 yr; 32 ± 2 kg/m(2)) and 10 lean controls (Lean-CON, 49 ± 3 yr; 23 ± 1 kg/m(2)), underwent bolus infusions of sodium nitroprusside (100 ?g) followed 60 s later by phenylephrine (150 ?g) and weighted linear regression performed. No group differences in overall sympathetic baroreflex gain were observed (T2D: -2.5 ± 0.3 vs. WM-CON: -2.6 ± 0.2 vs. Lean-CON: -2.7 ± 0.4 arbitrary units·beat·mmHg(-1), P > 0.05) or in sympathetic baroreflex gain when derived separately during blood pressure (BP) falls (nitroprusside) and BP rises (phenylephrine). In contrast, overall cardiac baroreflex gain was reduced in T2D patients compared with Lean-CON (T2D: 8.2 ± 1.5 vs. Lean-CON: 15.6 ± 2.9 ms·mmHg(-1), P < 0.05) and also tended to be reduced in WM-CON (9.3 ± 1.9 ms·mmHg(-1)) compared with Lean-CON (P = 0.059). Likewise, during BP rises, cardiac baroreflex gain was reduced in T2D patients and weight-matched controls compared with lean controls (P < 0.05), whereas no group differences were found during BP falls (P > 0.05). Sympathetic and cardiac ABR gains were comparable between normotensive and hypertensive T2D patients (P > 0.05). These findings suggest preserved ABR control of MSNA in T2D patients compared with both obese and lean age-matched counterparts, with a selective impairment in ABR HR control in T2D that may be related to obesity. Twit Text FOAVip Arterial baroreflex control of sympathetic nerve activity and heart rate in patients with type 2 diabetes ????Am J Physiol Heart Circ Physiol http://www.kidney.de/pget.php?&tw=1&pmid=27591221 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27591221 #FOAvip English Wikipedia <ref>{{Cite pmid|27591221 }}</ref> Arterial baroreflex control of sympathetic nerve activity and heart rate in patients with type 2 diabetes #MMPMID27591221 Holwerda SW ; Vianna LC ; Restaino RM ; Chaudhary K ; Young CN ; Fadel PJ Am J Physiol Heart Circ Physiol 2016[Nov]; 311 (5 ): H1170-H1179 PMID27591221 show ga Despite greater blood pressure reactivity to acute cardiovascular stressors and a higher prevalence of hypertension in type 2 diabetes (T2D) patients, limited information is available regarding arterial baroreflex (ABR) control in T2D. We hypothesized that ABR control of muscle sympathetic nerve activity (MSNA) and heart rate (HR) are attenuated in T2D patients. Seventeen T2D patients (50 ± 2 yr; 31 ± 1 kg/m(2)), 9 weight-matched controls (WM-CON, 46 ± 2 yr; 32 ± 2 kg/m(2)) and 10 lean controls (Lean-CON, 49 ± 3 yr; 23 ± 1 kg/m(2)), underwent bolus infusions of sodium nitroprusside (100 ?g) followed 60 s later by phenylephrine (150 ?g) and weighted linear regression performed. No group differences in overall sympathetic baroreflex gain were observed (T2D: -2.5 ± 0.3 vs. WM-CON: -2.6 ± 0.2 vs. Lean-CON: -2.7 ± 0.4 arbitrary units·beat·mmHg(-1), P > 0.05) or in sympathetic baroreflex gain when derived separately during blood pressure (BP) falls (nitroprusside) and BP rises (phenylephrine). In contrast, overall cardiac baroreflex gain was reduced in T2D patients compared with Lean-CON (T2D: 8.2 ± 1.5 vs. Lean-CON: 15.6 ± 2.9 ms·mmHg(-1), P < 0.05) and also tended to be reduced in WM-CON (9.3 ± 1.9 ms·mmHg(-1)) compared with Lean-CON (P = 0.059). Likewise, during BP rises, cardiac baroreflex gain was reduced in T2D patients and weight-matched controls compared with lean controls (P < 0.05), whereas no group differences were found during BP falls (P > 0.05). Sympathetic and cardiac ABR gains were comparable between normotensive and hypertensive T2D patients (P > 0.05). These findings suggest preserved ABR control of MSNA in T2D patients compared with both obese and lean age-matched counterparts, with a selective impairment in ABR HR control in T2D that may be related to obesity. |Adult [MESH] |Arteries/physiopathology [MESH] |Baroreflex/*drug effects [MESH] |Blood Pressure/drug effects [MESH] |Case-Control Studies [MESH] |Diabetes Mellitus, Type 2/complications/*physiopathology [MESH] |Female [MESH] |Heart Rate/*drug effects [MESH] |Humans [MESH] |Linear Models [MESH] |Male [MESH] |Middle Aged [MESH] |Muscle, Skeletal/innervation [MESH] |Nitroprusside/*pharmacology [MESH] |Obesity/complications/*physiopathology [MESH] |Phenylephrine/*pharmacology [MESH] |Sympathetic Nervous System/*drug effects [MESH] |Vasoconstrictor Agents/*pharmacology [MESH]Arterial baroreflex control of sympathetic nerve activity and heart ra(epmc).pdf DeepDyve Pubget Overpricing