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10.1158/0008-5472.CAN-16-1949 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-16-1949 C5243151!5243151!27815387     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Res 2017 ; 77 (2): 412-22 Nephropedia Template TP {{tp|p=27815387|t=2017. Polycomb-mediated disruption of an androgen receptor feedback loop drives castration-resistant prostate cancer |pdf=|usr=}}{{27815387}} gab.com Text Polycomb-mediated disruption of an androgen receptor feedback loop drives castration-resistant prostate cancer JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=27815387 #FOAvip The lethal phenotype of castration-resistant prostate cancer (CRPC) is generally caused by augmented signaling from the androgen receptor (AR). Here we report that the AR-repressed gene CCN3/NOV inhibits AR signaling and acts in a negative feedback loop to block AR function. Mechanistically, a cytoplasmic form of CCN3 interacted with the AR N-terminal domain to sequester AR in the cytoplasm of prostate cancer cells, thereby reducing AR transcriptional activity and inhibiting cell growth. However, constitutive repression of CCN3 by the Polycomb Group Protein EZH2 disrupted this negative feedback loop in both CRPC and enzalutamide-resistant prostate cancer cells. Notably, restoring CCN3 was sufficient to effectively abolish CPRC cell growth in vitro and in vivo. Taken together, our findings establish CCN3 as a pivotal regulator of AR signaling and prostate cancer progression and they establish a functional intersection between Polycomb and AR signaling in CRPC. Twit Text FOAVip Polycomb-mediated disruption of an androgen receptor feedback loop drives castration-resistant prostate cancer ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=27815387 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27815387 #FOAvip English Wikipedia <ref>{{Cite pmid|27815387}}</ref> Polycomb-mediated disruption of an androgen receptor feedback loop drives castration-resistant prostate cancer #MMPMID27815387 Fong Kw; Zhao JC; Kim J; Li S; Yang YA; Song B; Rittie L; Hu M; Yang X; Perbal B; Yu J Cancer Res 2017[Jan]; 77 (2): 412-22 PMID27815387show ga The lethal phenotype of castration-resistant prostate cancer (CRPC) is generally caused by augmented signaling from the androgen receptor (AR). Here we report that the AR-repressed gene CCN3/NOV inhibits AR signaling and acts in a negative feedback loop to block AR function. Mechanistically, a cytoplasmic form of CCN3 interacted with the AR N-terminal domain to sequester AR in the cytoplasm of prostate cancer cells, thereby reducing AR transcriptional activity and inhibiting cell growth. However, constitutive repression of CCN3 by the Polycomb Group Protein EZH2 disrupted this negative feedback loop in both CRPC and enzalutamide-resistant prostate cancer cells. Notably, restoring CCN3 was sufficient to effectively abolish CPRC cell growth in vitro and in vivo. Taken together, our findings establish CCN3 as a pivotal regulator of AR signaling and prostate cancer progression and they establish a functional intersection between Polycomb and AR signaling in CRPC. äPolycomb-mediated disruption of an androgen receptor feedback loop dri(epmc).pdf DeepDyve Pubget Overpricing